PMID- 22086146
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20210103
IS  - 1662-8128 (Electronic)
IS  - 1662-811X (Linking)
VI  - 4
IP  - 1
DP  - 2012
TI  - Dendritic cells and damage-associated molecular patterns: endogenous danger 
      signals linking innate and adaptive immunity.
PG  - 6-15
LID - 10.1159/000334245 [doi]
AB  - Dendritic cells (DCs) are potent antigen-presenting cells critical in regulating 
      the adaptive immune response. The role of DCs is dichotomous; they may both 
      present antigens and the appropriate stimulatory molecules to initiate an 
      adaptive immune response, or they may induce tolerance and release 
      anti-inflammatory signals. The activation of immature DCs, required for the 
      expression of the necessary costimulatory T cell molecules, is dependent on 
      pattern recognition receptors. In addition to the pathogen-derived ligands of 
      pattern recognition receptors, several damage-associated molecular patterns 
      (DAMPs) have recently been shown to interact with DCs and dramatically affect 
      their ultimate function. The complex interplay of DAMPs on DCs is clinically 
      important, with implications for transplantation, tumor immunity, autoimmunity, 
      chronic inflammation and other conditions of sterile inflammation such as 
      ischemia reperfusion injury. In this review, we will focus on the role of DAMPs 
      in DC function.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Nace, Gary
AU  - Nace G
AD  - Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, 
      USA.
FAU - Evankovich, John
AU  - Evankovich J
FAU - Eid, Raymond
AU  - Eid R
FAU - Tsung, Allan
AU  - Tsung A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111111
PL  - Switzerland
TA  - J Innate Immun
JT  - Journal of innate immunity
JID - 101469471
SB  - IM
MH  - Adaptive Immunity/*physiology
MH  - Animals
MH  - Antigen Presentation/*physiology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune Tolerance/physiology
MH  - Immunity, Innate/*physiology
MH  - Inflammation/immunology
MH  - Neoplasms/immunology
MH  - Organ Transplantation
MH  - Reperfusion Injury/immunology
MH  - Signal Transduction/*immunology
EDAT- 2011/11/17 06:00
MHDA- 2012/04/17 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/05/15 00:00 [received]
PHST- 2011/10/10 00:00 [accepted]
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
AID - 000334245 [pii]
AID - 10.1159/000334245 [doi]
PST - ppublish
SO  - J Innate Immun. 2012;4(1):6-15. doi: 10.1159/000334245. Epub 2011 Nov 11.