PMID- 22086392
OWN - NLM
STAT- MEDLINE
DCOM- 20120308
LR  - 20111117
IS  - 1549-5485 (Electronic)
IS  - 1072-0502 (Linking)
VI  - 18
IP  - 12
DP  - 2011 Dec
TI  - The cellular mechanisms of memory are modified by experience.
PG  - 747-50
LID - 10.1101/lm.024026.111 [doi]
AB  - The N-methyl-D-aspartate receptor (NMDAR) is thought to be essential for synaptic 
      plasticity and learning. However, recent work indicates that the role of this 
      receptor depends on the prior history of the research subject. For example, 
      animals trained on a hippocampus-dependent learning task are subsequently able to 
      acquire new information in the absence of NMDAR activation. The current 
      experiments were designed to identify the types of experiences that lead to 
      NMDAR-independent learning. Using contextual fear conditioning in mice, we find 
      that NMDAR-independent learning is only observed when (1) animals are trained on 
      the same behavioral task and (2) initial learning is successfully encoded into 
      long-term memory.
CI  - (c) 2011 Cold Spring Harbor Laboratory Press
FAU - Wiltgen, Brian J
AU  - Wiltgen BJ
AD  - Department of Psychology, University of Virginia, Charlottesville, Virginia 
      22904, USA. bw4fh@virginia.edu
FAU - Wood, Alynda N
AU  - Wood AN
FAU - Levy, Brynne
AU  - Levy B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111115
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Animals
MH  - Brain/*physiology
MH  - Conditioning, Classical
MH  - Learning/*physiology
MH  - Memory/*physiology
MH  - Mice
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
EDAT- 2011/11/17 06:00
MHDA- 2012/03/09 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/03/09 06:00 [medline]
AID - 18/12/747 [pii]
AID - 10.1101/lm.024026.111 [doi]
PST - epublish
SO  - Learn Mem. 2011 Nov 15;18(12):747-50. doi: 10.1101/lm.024026.111. Print 2011 Dec.