PMID- 22087033
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20211021
IS  - 1937-9145 (Electronic)
IS  - 1945-0877 (Linking)
VI  - 4
IP  - 199
DP  - 2011 Nov 15
TI  - The long-term survival potential of mature T lymphocytes is programmed during 
      development in the thymus.
PG  - ra77
LID - 10.1126/scisignal.2002246 [doi]
AB  - The homeostatic maintenance of normal numbers of mature T lymphocytes in the 
      immune system depends on signaling from the T cell antigen receptor (TCR) and the 
      interleukin-7 receptor (IL-7R); however, it is unclear whether there is crosstalk 
      between these two receptors. Here, we have identified a central role for TCR 
      signaling during the development of T lymphocytes in the thymus in the 
      determination of IL-7 function in mature T lymphocytes. We showed that Il7r 
      expression in mature T cells was modulated by developmental TCR-dependent signals 
      elicited during the process of positive selection in the thymus and that this 
      mechanism was common to both CD4(+) and CD8(+) T cells. Control of Il7r 
      expression by the TCR was limited to thymocytes because neither the abundance nor 
      the function of IL-7Ralpha was affected by TCR signaling in peripheral T cells. 
      Finally, we showed that thymocytes without optimal IL-7Ralpha abundance failed to 
      form part of the pool of mature T lymphocytes that patrol the periphery of normal 
      hosts, highlighting the importance of this mechanism in shaping the repertoire of 
      lymphocytes that make up this population.
FAU - Sinclair, Charles
AU  - Sinclair C
AD  - Division of Immune Cell Biology, Medical Research Council, National Institute for 
      Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
FAU - Saini, Manoj
AU  - Saini M
FAU - Schim van der Loeff, Ina
AU  - Schim van der Loeff I
FAU - Sakaguchi, Shimon
AU  - Sakaguchi S
FAU - Seddon, Benedict
AU  - Seddon B
LA  - eng
GR  - MC_U117573801/MRC_/Medical Research Council/United Kingdom
GR  - U117573801/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111115
PL  - United States
TA  - Sci Signal
JT  - Science signaling
JID - 101465400
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Receptors, Interleukin-7)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/cytology/*immunology
MH  - CD8-Positive T-Lymphocytes/cytology/*immunology/metabolism
MH  - Cell Survival
MH  - Gene Expression Regulation/immunology
MH  - Mice
MH  - Mice, Knockout
MH  - Receptors, Antigen, T-Cell/genetics/immunology/metabolism
MH  - Receptors, Interleukin-7/biosynthesis/immunology
MH  - Signal Transduction/*immunology
MH  - Thymocytes/cytology/*immunology/metabolism
MH  - Thymus Gland/cytology/*immunology/metabolism
EDAT- 2011/11/17 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - 4/199/ra77 [pii]
AID - 10.1126/scisignal.2002246 [doi]
PST - epublish
SO  - Sci Signal. 2011 Nov 15;4(199):ra77. doi: 10.1126/scisignal.2002246.