PMID- 22087208
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111123
LR  - 20211021
IS  - 2005-5013 (Electronic)
IS  - 1738-6586 (Print)
IS  - 1738-6586 (Linking)
VI  - 7
IP  - 3
DP  - 2011 Sep
TI  - Polymorphism of the Glutamate Transporter Protein EAAT2 and Migraine 
      Transformation into Chronic Daily Headache.
PG  - 143-7
LID - 10.3988/jcn.2011.7.3.143 [doi]
AB  - BACKGROUND AND PURPOSE: The progression of migraine into chronic daily headache 
      involves multiple risk factors, but the main contributor is not known. Glutamate 
      is the major excitatory neurotransmitter in central sensitization, which is an 
      important process in the pathogenesis of migraine transformation. The glutamate 
      transporter protein excitatory amino acid transporter 2 (EAAT2) is the primary 
      modulator of glutamatergic neurotransmission, and genetic polymorphisms of its 
      gene, EEAT2, have been identified. The aim of this study was to determine the 
      effect of EAAT2 polymorphisms on migraine transformation into chronic daily 
      headache. METHODS: We included 74 migraine patients with episodic attack (M-E) 
      and 59 migraine patients with chronic daily headache (M-CDH). After amplifying 
      EAAT2 by polymerase chain reaction, we assessed its genotype frequencies based on 
      restriction fragment length polymorphisms. We reclassified all migraine patients 
      into two groups according to their EAAT2 genotype, either with the A allele 
      (n=62) or without it (n=71), and compared the clinical variables between the two 
      groups. RESULTS: The genotype frequencies of EAAT2 polymorphisms did not differ 
      between the M-E and M-CDH groups. Comparison between EEAT2 genotypes revealed 
      that the frequency of analgesic usage was significantly higher among migraine 
      patients with the A allele (12.9+/-1.6 days/month) than in those without the A 
      allele (8.1+/-1.2 days/month; p=0.019). The other clinical variables of migraine 
      did not differ between the two groups. CONCLUSIONS: The results suggest that 
      EEAT2 polymorphism contributes to the tendency toward frequent analgesic usage in 
      migraine patients. This implies a potential genetic influence on the progression 
      of migraine into chronic daily headache through the development of 
      medication-overuse headache.
FAU - Shin, Hae-Eun
AU  - Shin HE
AD  - Department of Neurology, The Catholic University of Korea College of Medicine, 
      Uijeongbu St. Mary's Hospital, Uijeongbu, Korea.
FAU - Han, Soo-Jeong
AU  - Han SJ
FAU - Lee, Kwang-Soo
AU  - Lee KS
FAU - Park, Jeong-Wook
AU  - Park JW
LA  - eng
PT  - Journal Article
DEP - 20110929
PL  - Korea (South)
TA  - J Clin Neurol
JT  - Journal of clinical neurology (Seoul, Korea)
JID - 101252374
PMC - PMC3212600
OTO - NOTNLM
OT  - chronic daily headache
OT  - glutamate transporter protein
OT  - migraine
OT  - polymorphism
COIS- The authors have no financial conflicts of interest.
EDAT- 2011/11/17 06:00
MHDA- 2011/11/17 06:01
PMCR- 2011/09/01
CRDT- 2011/11/17 06:00
PHST- 2010/10/21 00:00 [received]
PHST- 2011/01/03 00:00 [revised]
PHST- 2011/01/03 00:00 [accepted]
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2011/11/17 06:01 [medline]
PHST- 2011/09/01 00:00 [pmc-release]
AID - 10.3988/jcn.2011.7.3.143 [doi]
PST - ppublish
SO  - J Clin Neurol. 2011 Sep;7(3):143-7. doi: 10.3988/jcn.2011.7.3.143. Epub 2011 Sep 
      29.