PMID- 22087250
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 11
DP  - 2011
TI  - Elevated levels of the vesicular monoamine transporter and a novel repetitive 
      behavior in the Drosophila model of fragile X syndrome.
PG  - e27100
LID - 10.1371/journal.pone.0027100 [doi]
LID - e27100
AB  - Fragile X Syndrome (FXS) is characterized by mental impairment and autism in 
      humans, and it often features hyperactivity and repetitive behaviors. The 
      mechanisms for the disease, however, remain poorly understood. Here we report 
      that the dfmr1 mutant in the Drosophila model of FXS grooms excessively, which 
      may be regulated differentially by two signaling pathways. Blocking metabotropic 
      glutamate receptor signaling enhances grooming in dfmr1 mutant flies, whereas 
      blocking the vesicular monoamine transporter (VMAT) suppresses excessive 
      grooming. dfmr1 mutant flies also exhibit elevated levels of VMAT mRNA and 
      protein. These results suggest that enhanced monoamine signaling correlates with 
      repetitive behaviors and hyperactivity associated with FXS.
FAU - Tauber, John M
AU  - Tauber JM
AD  - Department of Zoology, University of Oklahoma, Norman, Oklahoma, United States of 
      America.
FAU - Vanlandingham, Phillip A
AU  - Vanlandingham PA
FAU - Zhang, Bing
AU  - Zhang B
LA  - eng
GR  - R01 NS060878/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111102
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Drosophila Proteins)
RN  - 0 (FMR1 protein, Drosophila)
RN  - 0 (RNA, Messenger)
RN  - 0 (Vesicular Monoamine Transport Proteins)
RN  - 139135-51-6 (Fragile X Mental Retardation Protein)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Disease Models, Animal
MH  - Drosophila Proteins
MH  - Drosophila melanogaster/*metabolism
MH  - Fragile X Mental Retardation Protein
MH  - Fragile X Syndrome/etiology/*physiopathology
MH  - Grooming
MH  - Obsessive Behavior/*etiology
MH  - RNA, Messenger/analysis
MH  - Signal Transduction
MH  - Vesicular Monoamine Transport Proteins/analysis/*metabolism
PMC - PMC3206932
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2011/11/17 06:00
MHDA- 2012/05/19 06:00
PMCR- 2011/11/02
CRDT- 2011/11/17 06:00
PHST- 2011/06/30 00:00 [received]
PHST- 2011/10/10 00:00 [accepted]
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
PHST- 2011/11/02 00:00 [pmc-release]
AID - PONE-D-11-12273 [pii]
AID - 10.1371/journal.pone.0027100 [doi]
PST - ppublish
SO  - PLoS One. 2011;6(11):e27100. doi: 10.1371/journal.pone.0027100. Epub 2011 Nov 2.