PMID- 22087305
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20240317
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 11
DP  - 2011
TI  - BDNF polymorphism predicts general intelligence after penetrating traumatic brain 
      injury.
PG  - e27389
LID - 10.1371/journal.pone.0027389 [doi]
LID - e27389
AB  - Neuronal plasticity is a fundamental factor in cognitive outcome following 
      traumatic brain injury. Brain-derived neurotrophic factor (BDNF), a member of the 
      neurotrophin family, plays an important role in this process. While there are 
      many ways to measure cognitive outcome, general cognitive intelligence is a 
      strong predictor of everyday decision-making, occupational attainment, social 
      mobility and job performance. Thus it is an excellent measure of cognitive 
      outcome following traumatic brain injury (TBI). Although the importance of the 
      single-nucleotide polymorphisms polymorphism on cognitive function has been 
      previously addressed, its role in recovery of general intelligence following TBI 
      is unknown. We genotyped male Caucasian Vietnam combat veterans with focal 
      penetrating TBI (pTBI) (n = 109) and non-head injured controls (n = 38) for 7 
      BDNF single-nucleotide polymorphisms. Subjects were administrated the Armed 
      Forces Qualification Test (AFQT) at three different time periods: pre-injury on 
      induction into the military, Phase II (10-15 years post-injury, and Phase III 
      (30-35 years post-injury). Two single-nucleotide polymorphisms, rs7124442 and 
      rs1519480, were significantly associated with post-injury recovery of general 
      cognitive intelligence with the most pronounced effect at the Phase II time 
      point, indicating lesion-induced plasticity. The genotypes accounted for 5% of 
      the variance of the AFQT scores, independently of other significant predictors 
      such as pre-injury intelligence and percentage of brain volume loss. These data 
      indicate that genetic variations in BDNF play a significant role in 
      lesion-induced recovery following pTBI. Identifying the underlying mechanism of 
      this brain-derived neurotrophic factor effect could provide insight into an 
      important aspect of post-traumatic cognitive recovery.
FAU - Rostami, Elham
AU  - Rostami E
AD  - Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
FAU - Krueger, Frank
AU  - Krueger F
FAU - Zoubak, Serguei
AU  - Zoubak S
FAU - Dal Monte, Olga
AU  - Dal Monte O
FAU - Raymont, Vanessa
AU  - Raymont V
FAU - Pardini, Matteo
AU  - Pardini M
FAU - Hodgkinson, Colin A
AU  - Hodgkinson CA
FAU - Goldman, David
AU  - Goldman D
FAU - Risling, Marten
AU  - Risling M
FAU - Grafman, Jordan
AU  - Grafman J
LA  - eng
GR  - Z01 AA000301-09/ImNIH/Intramural NIH HHS/United States
GR  - Z01 AA000301-10/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111108
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Brain Injuries/*complications
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cognition
MH  - Head Injuries, Penetrating/*complications
MH  - Humans
MH  - Intelligence/*genetics
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Predictive Value of Tests
MH  - Recovery of Function/*genetics
PMC - PMC3210804
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2011/11/17 06:00
MHDA- 2012/05/19 06:00
PMCR- 2011/11/08
CRDT- 2011/11/17 06:00
PHST- 2011/06/30 00:00 [received]
PHST- 2011/10/15 00:00 [accepted]
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
PHST- 2011/11/08 00:00 [pmc-release]
AID - PONE-D-11-12350 [pii]
AID - 10.1371/journal.pone.0027389 [doi]
PST - ppublish
SO  - PLoS One. 2011;6(11):e27389. doi: 10.1371/journal.pone.0027389. Epub 2011 Nov 8.