PMID- 22090393
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20111117
IS  - 1940-2465 (Electronic)
IS  - 1066-8969 (Linking)
VI  - 19
IP  - 5
DP  - 2011 Oct
TI  - Composite mantle cell and diffuse large B-cell lymphoma: report of two cases.
PG  - 643-8
LID - 10.1177/1066896911405656 [doi]
AB  - Composite lymphomas are rare and involve the concurrent evolution of 2 distinct 
      lymphoma types within a single organ or tissue. This study describes 2 cases of 
      composite mantle cell lymphoma (MCL) and diffuse large B-cell lymphoma (DLBCL), 
      which has not previously been reported. Each case demonstrated distinct 
      populations of CD20 positive small and large atypical B cells. In both cases, 
      only the small lymphocytes were positive for CD5 and cyclin D1, and fluorescence 
      in situ hybridization (FISH) showed a t(11;14) translocation in the small 
      lymphocytes but not in the large cells. Molecular studies for B-cell clonality 
      showed a possible clonal relationship between the 2 components in one case but 
      not the other. This study describes in detail the morphology, immunophenotype, 
      FISH, and molecular analysis of both components in each case. To the authors' 
      knowledge, this represents the first report of juxtaposition of MCL with DLBCL 
      that does not represent transformation of the mantle cell component.
FAU - Ho, Albert K
AU  - Ho AK
AD  - University of Utah, Salt Lake City, UT, USA. albert.ho@hsc.utah.edu
FAU - Teman, Carolin J
AU  - Teman CJ
FAU - Smith, Gregory P
AU  - Smith GP
FAU - Nightingale, Daniel R
AU  - Nightingale DR
FAU - Miles, Rodney R
AU  - Miles RR
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Int J Surg Pathol
JT  - International journal of surgical pathology
JID - 9314927
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Humans
MH  - Immunohistochemistry
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Laser Capture Microdissection
MH  - Lymphoma, Large B-Cell, Diffuse/genetics/metabolism/*pathology
MH  - Lymphoma, Mantle-Cell/genetics/metabolism/*pathology
MH  - Male
MH  - Neoplasms, Multiple Primary/genetics/metabolism/*pathology
MH  - Polymerase Chain Reaction
EDAT- 2011/11/18 06:00
MHDA- 2012/03/08 06:00
CRDT- 2011/11/18 06:00
PHST- 2011/11/18 06:00 [entrez]
PHST- 2011/11/18 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
AID - 19/5/643 [pii]
AID - 10.1177/1066896911405656 [doi]
PST - ppublish
SO  - Int J Surg Pathol. 2011 Oct;19(5):643-8. doi: 10.1177/1066896911405656.