PMID- 22090723
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111123
LR  - 20211021
IS  - 0971-6866 (Print)
IS  - 1998-362X (Electronic)
IS  - 1998-362X (Linking)
VI  - 17
IP  - 2
DP  - 2011 May
TI  - Deletion of ABL/BCR on der(9) associated with severe basophilia.
PG  - 100-3
LID - 10.4103/0971-6866.86198 [doi]
AB  - Chronic basophilic leukemia is a rare form in chronic myeloid leukemia patients. 
      Only limited number of reports are available. Herein, we describe a patient who 
      presented with fatigue, weight loss, leucocytosis, prominent basophilia, and mild 
      eosinophilia. On biopsy, bone marrow was hypercellular with marked basophils. The 
      immunophenotype showed abnormal expression of CD7, which is suggestive of 
      basophilic maturation. Chromosomal analysis from GTG-banded metaphases revealed 
      Ph positivity, and fluorescence in situ hybridization (FISH) with BCR/ABL dual 
      color, dual fusion probe showed single fusion on the der(22) chromosome and 
      ABL/BCR fusion was deleted on the der(9) chromosome. The deletion (ABL/BCR) on 
      der(9) may be associated with basophilia which may be also indicative of the 
      transformation of CML to acute myeloid leukemia.
FAU - Vaidya, Shantashri
AU  - Vaidya S
AD  - Department of Cytogenetics, National Institute of Immunohaematology (ICMR), 
      K.E.M. Hospital Campus, Parel, Mumbai, India.
FAU - Madkaikar, Manisha
AU  - Madkaikar M
FAU - Ghosh, Kanjaksha
AU  - Ghosh K
FAU - Vundinti, Babu Rao
AU  - Vundinti BR
LA  - eng
PT  - Case Reports
PL  - India
TA  - Indian J Hum Genet
JT  - Indian journal of human genetics
JID - 101223637
PMC - PMC3214311
OTO - NOTNLM
OT  - BCR/ABL deletions
OT  - Basophilia
OT  - chronic myeloid leukemia
COIS- Conflict of Interest: None declared.
EDAT- 2011/11/18 06:00
MHDA- 2011/11/18 06:01
PMCR- 2011/05/01
CRDT- 2011/11/18 06:00
PHST- 2011/11/18 06:00 [entrez]
PHST- 2011/11/18 06:00 [pubmed]
PHST- 2011/11/18 06:01 [medline]
PHST- 2011/05/01 00:00 [pmc-release]
AID - IJHG-17-100 [pii]
AID - 10.4103/0971-6866.86198 [doi]
PST - ppublish
SO  - Indian J Hum Genet. 2011 May;17(2):100-3. doi: 10.4103/0971-6866.86198.