PMID- 22092747
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20130325
IS  - 1600-0838 (Electronic)
IS  - 0905-7188 (Linking)
VI  - 23
IP  - 2
DP  - 2013 Mar
TI  - Inflammation and oxidative stress are lower in physically fit and active adults.
PG  - 215-23
LID - 10.1111/j.1600-0838.2011.01373.x [doi]
AB  - The objective of this study was to determine if the inverse relationship between 
      perceived physical fitness (pFIT) and exercise frequency (ExFreq) levels and 
      chronic inflammation and oxidative stress exists after making statistical 
      adjustments for confounders including body mass index (BMI), age, gender, and 
      cigarette smoking. Study participants (60% female and 40% male; n = 998) varied 
      widely in age (18-85 years) and BMI (16.7-52.7 kg/m(2)) completed an extensive 
      medical/health and lifestyle questionnaire, and data were used to establish pFIT 
      and ExFreq tertiles. Biomarkers included serum C-reactive protein (CRP), total 
      blood leukocytes, five plasma cytokines [interleukin (IL)-6, IL-10, tumor 
      necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP1), and 
      granulocyte colony-stimulating factor (GCSF)], F2 -isoprostanes, ferric reducing 
      ability of plasma (FRAP), and oxygen radical absorbance capacity (ORAC). A 
      general linear model was used to examine relationships between pFIT and ExFreq 
      with inflammation and oxidative stress while controlling for age, gender, BMI, 
      and smoking. Benjamini-Hochberg method for false discovery rate correction was 
      used for multiple testing corrections. Significant tests (P < 0.05) for trend 
      were found for the effect of pFIT and ExFreq on CRP, white blood cell, IL-6, 
      TNF-alpha, GCSF, and F2 -isoprostanes, but not MCP1, IL-10, FRAP, and ORAC, after 
      adjustment for confounders. These data indicate that an inverse relationship 
      exists among chronic inflammation, oxidative stress, and pFIT and ExFreq at the 
      community level even after adjustment for important confounders.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Shanely, R A
AU  - Shanely RA
AD  - Human Performance Laboratory, Appalachian State University, North Carolina 
      Research Campus, Kannapolis, North Carolina 28081, USA. shanelyra@appstate.edu
FAU - Nieman, D C
AU  - Nieman DC
FAU - Henson, D A
AU  - Henson DA
FAU - Jin, F
AU  - Jin F
FAU - Knab, A M
AU  - Knab AM
FAU - Sha, W
AU  - Sha W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110818
PL  - Denmark
TA  - Scand J Med Sci Sports
JT  - Scandinavian journal of medicine & science in sports
JID - 9111504
RN  - 0 (Cytokines)
RN  - 0 (F2-Isoprostanes)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - C-Reactive Protein/analysis
MH  - Cytokines/blood
MH  - Exercise/*physiology
MH  - F2-Isoprostanes/blood
MH  - Female
MH  - Humans
MH  - Inflammation/*blood
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/*physiology
MH  - Physical Fitness/*physiology
MH  - Young Adult
EDAT- 2011/11/19 06:00
MHDA- 2013/09/21 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/06/20 00:00 [accepted]
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - 10.1111/j.1600-0838.2011.01373.x [doi]
PST - ppublish
SO  - Scand J Med Sci Sports. 2013 Mar;23(2):215-23. doi: 
      10.1111/j.1600-0838.2011.01373.x. Epub 2011 Aug 18.