PMID- 22093089
OWN - NLM
STAT- MEDLINE
DCOM- 20120611
LR  - 20120213
IS  - 1399-3062 (Electronic)
IS  - 1398-2273 (Linking)
VI  - 14
IP  - 1
DP  - 2012 Feb
TI  - Analysis of rotavirus antigenemia in hematopoietic stem cell transplant 
      recipients.
PG  - 49-56
LID - 10.1111/j.1399-3062.2011.00668.x [doi]
AB  - Systemic rotavirus infection, such as rotavirus antigenemia, has been found in 
      immunocompetent rotavirus gastroenteritis patients. However, the pathogenesis of 
      rotavirus infection in immunocompromised transplant recipients remains unclear. 
      Enzyme-linked immunosorbent assay was used to measure rotavirus antigen levels in 
      serially collected serum samples obtained from 62 pediatric patients receiving 
      allogeneic hematopoietic stem cell transplants (HSCT). Rotavirus antigen was 
      detected in 43 (6.8%) of 633 serum samples (8 of 62 patients). The duration of 
      rotavirus antigenemia ranged between 1 and 10 weeks, and diarrhea was concurrent 
      with rotavirus antigenemia in Cases 3, 6, 7, and 8. The level of viral antigen in 
      the transplant recipients (0.19 +/- 0.20) was significantly lower than that 
      observed in serum samples collected from immunocompetent patients on either day 1 
      (0.49 +/- 0.18, P = 0.0011) or day 3 (0.63 +/- 0.09, P = 0.0005). A patient who 
      received a graft from a human leukocyte antigen (HLA)-mismatched donor was at 
      significant risk for rotavirus antigenemia (P = 0.024; odds ratio = 9.44) in 
      comparison to patients who received grafts from HLA-matched donors. Although the 
      duration of antigenemia was clearly longer in HSCT patients than in 
      immunocompetent rotavirus gastroenteritis patients, the levels of viral antigen 
      were not as high. Therefore, mismatched HLA may be a risk factor for rotavirus 
      antigenemia after HSCT.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Sugata, K
AU  - Sugata K
AD  - Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, 
      Aichi, Japan.
FAU - Taniguchi, K
AU  - Taniguchi K
FAU - Yui, A
AU  - Yui A
FAU - Nakai, H
AU  - Nakai H
FAU - Asano, Y
AU  - Asano Y
FAU - Hashimoto, S
AU  - Hashimoto S
FAU - Ihira, M
AU  - Ihira M
FAU - Yagasaki, H
AU  - Yagasaki H
FAU - Takahashi, Y
AU  - Takahashi Y
FAU - Kojima, S
AU  - Kojima S
FAU - Matsumoto, K
AU  - Matsumoto K
FAU - Kato, K
AU  - Kato K
FAU - Yoshikawa, T
AU  - Yoshikawa T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110825
PL  - Denmark
TA  - Transpl Infect Dis
JT  - Transplant infectious disease : an official journal of the Transplantation 
      Society
JID - 100883688
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Antibodies, Viral/blood
MH  - Antigens, Viral/*blood
MH  - Child
MH  - Child, Preschool
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - HLA Antigens/immunology
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Infant
MH  - Male
MH  - Risk Factors
MH  - Rotavirus/*immunology/isolation & purification
MH  - Rotavirus Infections/blood/physiopathology/*virology
MH  - Transplantation, Homologous/adverse effects
MH  - Viremia/*immunology/virology
EDAT- 2011/11/19 06:00
MHDA- 2012/06/12 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/05/03 00:00 [received]
PHST- 2011/06/15 00:00 [revised]
PHST- 2011/06/20 00:00 [revised]
PHST- 2011/06/28 00:00 [accepted]
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/06/12 06:00 [medline]
AID - 10.1111/j.1399-3062.2011.00668.x [doi]
PST - ppublish
SO  - Transpl Infect Dis. 2012 Feb;14(1):49-56. doi: 10.1111/j.1399-3062.2011.00668.x. 
      Epub 2011 Aug 25.