PMID- 22094369
OWN - NLM
STAT- MEDLINE
DCOM- 20120425
LR  - 20220317
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 22
IP  - 1
DP  - 2012 Jan
TI  - Type 2 diabetes mellitus: a possible surgically reversible intestinal 
      dysfunction.
PG  - 167-76
LID - 10.1007/s11695-011-0563-2 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a global public health problem often 
      associated with obesity. Bariatric surgery is effective for treating serious 
      obesity, and techniques involving intestinal bypass have metabolic benefits, such 
      as complete and early remission of T2DM. We present a literature review of the 
      possible mechanisms of early normalization of glycemic homeostasis after 
      bariatric surgery, including intestinal gluconeogenesis, increased 
      antidiabetogenic signals from L cells located in the distal small intestine, and 
      impaired secretion of diabetogenic signals in the upper part of the small 
      intestine. Adding to these potential mechanisms, unknown factors that regulate 
      insulin sensitivity may be involved and altered by bariatric surgery. This review 
      discusses the various hypotheses about the mechanisms of glycemic control after 
      bariatric surgery involving intestinal bypass. Further research is essential to 
      better understand these mechanisms and to identify potential new mechanisms that 
      might help in developing less invasive and safer alternatives for the treatment 
      of T2DM and reveal novel pharmaceutical targets for glycemic control.
FAU - Sala, Priscila C
AU  - Sala PC
AD  - Department of Gastroenterology, Digestive Surgery Discipline, LIM 35, University 
      of Sao Paulo, Medical School, Av Dr Arnaldo, 455 Cerqueira Cesar, CEP 01246-930 
      Sao Paulo, Brazil. priscila_csala@hotmail.com
FAU - Torrinhas, Raquel S
AU  - Torrinhas RS
FAU - Heymsfield, Steven B
AU  - Heymsfield SB
FAU - Waitzberg, Dan L
AU  - Waitzberg DL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
RN  - 0 (Blood Glucose)
SB  - IM
MH  - *Bariatric Surgery/methods
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/*metabolism/surgery
MH  - Female
MH  - *Gluconeogenesis
MH  - Homeostasis
MH  - Humans
MH  - Intestine, Small/*metabolism/surgery
MH  - Male
MH  - Obesity, Morbid/*metabolism/surgery
MH  - Treatment Outcome
MH  - Weight Loss
EDAT- 2011/11/19 06:00
MHDA- 2012/04/26 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/04/26 06:00 [medline]
AID - 10.1007/s11695-011-0563-2 [doi]
PST - ppublish
SO  - Obes Surg. 2012 Jan;22(1):167-76. doi: 10.1007/s11695-011-0563-2.