PMID- 22095316
OWN - NLM
STAT- MEDLINE
DCOM- 20120305
LR  - 20211021
IS  - 1741-0444 (Electronic)
IS  - 0140-0118 (Print)
IS  - 0140-0118 (Linking)
VI  - 49
IP  - 12
DP  - 2011 Dec
TI  - Comparison of four mathematical models to analyze indicator-dilution curves in 
      the coronary circulation.
PG  - 1471-9
LID - 10.1007/s11517-011-0845-9 [doi]
AB  - While several models have proven to result in accurate estimations when measuring 
      cardiac output using indicator dilution, the mono-exponential model has primarily 
      been chosen for deriving coronary blood/plasma volume. In this study, we compared 
      four models to derive coronary plasma volume using indicator dilution; the 
      mono-exponential, power-law, gamma-variate, and local density random walk (LDRW) 
      model. In anesthetized goats (N = 14), we determined the distribution volume of 
      high molecular weight (2,000 kDa) dextrans. A bolus injection (1.0 ml, 
      0.65 mg/ml) was given intracoronary and coronary venous blood samples were taken 
      every 0.5-1.0 s; outflow curves were analyzed using the four aforementioned 
      models. Measurements were done at baseline and during adenosine infusion. 
      Absolute coronary plasma volume estimates varied by ~25% between models, while 
      the relative volume increase during adenosine infusion was similar for all 
      models. The gamma-variate, LDRW, and mono-exponential model resulted in volumes 
      corresponding with literature, whereas the power-model seemed to overestimate the 
      coronary plasma volume. The gamma-variate and LDRW model appear to be suitable 
      alternative models to the mono-exponential model to analyze coronary 
      indicator-dilution curves, particularly since these models are minimally 
      influenced by outliers and do not depend on data of the descending slope of the 
      curve only.
FAU - Brands, Judith
AU  - Brands J
AD  - Department of Physiology, Cardiovascular Research Institute Maastricht, 
      Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
FAU - Vink, Hans
AU  - Vink H
FAU - Van Teeffelen, Jurgen W G E
AU  - Van Teeffelen JW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111118
PL  - United States
TA  - Med Biol Eng Comput
JT  - Medical & biological engineering & computing
JID - 7704869
RN  - 0 (Vasodilator Agents)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine
MH  - Animals
MH  - Coronary Circulation/*physiology
MH  - Female
MH  - Goats
MH  - Hemodynamics/physiology
MH  - Indicator Dilution Techniques
MH  - *Models, Cardiovascular
MH  - Vasodilator Agents
PMC - PMC3223587
EDAT- 2011/11/19 06:00
MHDA- 2012/03/06 06:00
PMCR- 2011/11/18
CRDT- 2011/11/19 06:00
PHST- 2011/06/14 00:00 [received]
PHST- 2011/11/07 00:00 [accepted]
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/03/06 06:00 [medline]
PHST- 2011/11/18 00:00 [pmc-release]
AID - 845 [pii]
AID - 10.1007/s11517-011-0845-9 [doi]
PST - ppublish
SO  - Med Biol Eng Comput. 2011 Dec;49(12):1471-9. doi: 10.1007/s11517-011-0845-9. Epub 
      2011 Nov 18.