PMID- 22095460
OWN - NLM
STAT- MEDLINE
DCOM- 20120730
LR  - 20221207
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 131
IP  - 3
DP  - 2012 Aug 1
TI  - Human leukocyte antigen G polymorphism is associated with an increased risk of 
      invasive cancer of the uterine cervix.
PG  - E312-9
LID - 10.1002/ijc.27356 [doi]
AB  - Human leukocyte antigen (HLA)-G acts as negative regulator of the immune 
      responses and its expression in tumor cells may enable them to escape 
      immunosurveillance. The purpose of this study was to investigate the influence of 
      HLA-G polymorphism on risk of high-grade cervical intraepithelial neoplasia 
      (HG-CIN) and cervical cancer in a Canadian population. The authors have analyzed 
      1,372 women from participants recruited between 2001 and 2009 in the ongoing 
      Biomarkers of Cervical Cancer Risk case-control study. A total of 539 women with 
      histologically confirmed HG-CIN and invasive cancer formed the case series, and 
      833 women with normal cytology served as controls. Cervical specimens were tested 
      for human papillomavirus (HPV) DNA using the MY09/11 PCR protocol and HLA-G 
      alleles where determined using a direct DNA sequencing procedures. HLA-G 
      polymorphisms were not associated with HG-CIN or HPV infection. However, the risk 
      for invasive cancer was significantly increased with the homozygous genotypes 
      HLA-G*01:01:02 [odds ratio (OR) = 3.52, 95% confidence interval (CI): 1.43-8.61, 
      p = 0.006], -G*01:06 (OR = 19.1, 95% CI: 2.29-159, p = 0.005) and -G* 3'UTR 14-bp 
      insertion (OR = 2.17, 95% CI: 1.10-4.27, p = 0.020), whereas, the heterozygotic 
      form of the G*01:01:01 wild-type allele was significantly associated with a 
      reduced risk of invasive cancer (OR = 0.31, 95% CI: 0.16-0.59, p < 0.0001) after 
      adjusting for age, HPV infection and ethnicity. These associations were also 
      observed with progression of disease from HG-CIN to invasive cancer among 
      HPV-positive women. These results suggest that HLA-G polymorphism is an 
      independent risk factor for the development of invasive cervical cancer.
CI  - Copyright (c) 2011 UICC.
FAU - Ferguson, Rhea
AU  - Ferguson R
AD  - Department of Epidemiology, Biostatistics and Occupational Health, McGill 
      University, Montreal, Canada.
FAU - Ramanakumar, Agnihotram V
AU  - Ramanakumar AV
FAU - Koushik, Anita
AU  - Koushik A
FAU - Coutlee, Francois
AU  - Coutlee F
FAU - Franco, Eduardo
AU  - Franco E
FAU - Roger, Michel
AU  - Roger M
CN  - Biomarkers of Cervical Cancer Risk Study Team
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120103
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Adult
MH  - Base Sequence
MH  - Biomarkers, Tumor/genetics
MH  - Canada
MH  - Case-Control Studies
MH  - Disease Progression
MH  - Female
MH  - Genotype
MH  - HLA-G Antigens/*genetics/immunology
MH  - Humans
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Papillomaviridae/classification/genetics
MH  - Papillomavirus Infections/genetics/virology
MH  - Polymorphism, Single Nucleotide
MH  - Risk
MH  - Risk Factors
MH  - Sequence Analysis, DNA
MH  - Tumor Escape
MH  - Tumor Microenvironment
MH  - Uterine Cervical Neoplasms/*genetics/immunology/pathology/virology
MH  - Uterine Cervical Dysplasia/*genetics/immunology/pathology/virology
EDAT- 2011/11/19 06:00
MHDA- 2012/07/31 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/08/16 00:00 [received]
PHST- 2011/10/26 00:00 [accepted]
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/07/31 06:00 [medline]
AID - 10.1002/ijc.27356 [doi]
PST - ppublish
SO  - Int J Cancer. 2012 Aug 1;131(3):E312-9. doi: 10.1002/ijc.27356. Epub 2012 Jan 3.