PMID- 22095727
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20211021
IS  - 1524-4571 (Electronic)
IS  - 0009-7330 (Print)
IS  - 0009-7330 (Linking)
VI  - 110
IP  - 1
DP  - 2012 Jan 6
TI  - Circadian dependence of infarct size and left ventricular function after ST 
      elevation myocardial infarction.
PG  - 105-10
LID - 10.1161/CIRCRESAHA.111.254284 [doi]
AB  - RATIONALE: In rodents, infarct size after ischemia/reperfusion exhibits a 
      circadian dependence on the time of coronary occlusion. It is not known if a 
      similar circadian dependence of infarct size occurs in humans. OBJECTIVE: To 
      determine if humans exhibit a circadian dependence of infarct size in the setting 
      of ST elevation myocardial infarction (STEMI). METHODS AND RESULTS: A 
      retrospective analysis of 1031 patients with STEMI referred for primary 
      percutaneous coronary intervention with known ischemic times between 1 and 6 
      hours identified 165 patients with occluded arteries on presentation without 
      evidence of preinfarction angina or collateral blood flow. Both ischemic duration 
      and angiographic area at risk were not dependent on time of infarct onset. We 
      observed that the extent of infarct size measured by creatine kinase release was 
      significantly associated with time of day onset of infarction (P<0.0001). The 
      greatest myocardial injury occurred at 1:00 am onset of ischemia and 5:00 am 
      onset of reperfusion, with the peak creatine kinase measured at the peak of the 
      curve being 82% higher than that recorded at the trough. Similarly, left 
      ventricular ejection fraction measured within 2 days of infarction was also 
      dependent on time of onset of STEMI with the absolute left ventricular ejection 
      fraction at peak >7% higher than at trough (43% vs 51%; P<0.03). These findings 
      were supported by a subgroup of patients (n = 45) who underwent cardiac MRI 
      measurements of infarct size and area-at-risk measurements. CONCLUSIONS: The 
      results of this study demonstrate for the first time in humans that myocardial 
      infarct size and left ventricular function after STEMI have a circadian 
      dependence on the time of day onset of ischemia.
FAU - Reiter, Ronald
AU  - Reiter R
AD  - Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, 
      Minneapolis, MN 55407, USA.
FAU - Swingen, Cory
AU  - Swingen C
FAU - Moore, Luke
AU  - Moore L
FAU - Henry, Timothy D
AU  - Henry TD
FAU - Traverse, Jay H
AU  - Traverse JH
LA  - eng
GR  - R01 HL103927/HL/NHLBI NIH HHS/United States
GR  - R01 HL103927-02/HL/NHLBI NIH HHS/United States
GR  - 1-RO1HL103927/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111117
PL  - United States
TA  - Circ Res
JT  - Circulation research
JID - 0047103
RN  - EC 2.7.3.2 (Creatine Kinase, MB Form)
SB  - IM
CIN - Circ Res. 2012 Jan 6;110(1):6-7. PMID: 22223205
CIN - Circ Res. 2012 Feb 3;110(3):e22; author reply e23. PMID: 22302758
CIN - Circ Res. 2012 Apr 27;110(9):e67; author reply e68. PMID: 22539760
CIN - Circ Res. 2013 May 10;112(10):e110-4. PMID: 23661713
CIN - Circ Res. 2013 May 10;112(10):e115-7. PMID: 23661714
CIN - Circ Res. 2013 Aug 2;113(4):e43-4. PMID: 23908336
MH  - Aged
MH  - Circadian Rhythm/*physiology
MH  - Cohort Studies
MH  - Creatine Kinase, MB Form/metabolism
MH  - *Electrocardiography
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/metabolism/*pathology
MH  - Myocardial Reperfusion Injury/metabolism/pathology
MH  - Retrospective Studies
MH  - Ventricular Function, Left/*physiology
PMC - PMC3253266
MID - NIHMS342149
EDAT- 2011/11/19 06:00
MHDA- 2012/03/27 06:00
PMCR- 2013/01/06
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
PHST- 2013/01/06 00:00 [pmc-release]
AID - CIRCRESAHA.111.254284 [pii]
AID - 10.1161/CIRCRESAHA.111.254284 [doi]
PST - ppublish
SO  - Circ Res. 2012 Jan 6;110(1):105-10. doi: 10.1161/CIRCRESAHA.111.254284. Epub 2011 
      Nov 17.