PMID- 22096508
OWN - NLM
STAT- MEDLINE
DCOM- 20120410
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 11
DP  - 2011
TI  - Variation in effects of non-Hodgkin lymphoma risk factors according to the human 
      leukocyte antigen (HLA)-DRB1*01:01 allele and ancestral haplotype 8.1.
PG  - e26949
LID - 10.1371/journal.pone.0026949 [doi]
LID - e26949
AB  - Genetic variations in human leukocyte antigens (HLA) are critical in host 
      responses to infections, transplantation, and immunological diseases. We 
      previously identified associations with non-Hodgkin lymphoma (NHL) and the 
      HLA-DRB1*01:01 allele and extended ancestral haplotype (AH) 8.1 
      (HLA-A*01-B*08-DR*03-TNF-308A). To illuminate how HLA alleles and haplotypes may 
      influence NHL etiology, we examined potential interactions between HLA-DRB1*01:01 
      and AH 8.1, and a wide range of NHL risk factors among 685 NHL cases and 646 
      controls from a United States population-based case-control study. We calculated 
      odds ratios and 95% confidence intervals by HLA allele or haplotype status, 
      adjusted for sex, age, race and study center for NHL and two major subtypes using 
      polychotomous unconditional logistic regression models. The previously reported 
      elevation in NHL risk associated with exposures to termite treatment and 
      polychlorinated biphenyls were restricted to individuals who did not possess 
      HLA-DRB1*01:01. Previous associations for NHL and DLBCL with decreased sun 
      exposure, higher BMI, and autoimmune conditions were statistically significant 
      only among those with AH 8.1, and null among those without AH 8.1. Our results 
      suggest that NHL risk factors vary in their association based on HLA-DRB1*01:01 
      and AH 8.1 status. Our results further suggest that certain NHL risk factors may 
      act through a common mechanism to alter NHL risk. Finally, control participants 
      with either HLA-DRB1*01:01 or AH 8.1 reported having a family history of NHL 
      twice as likely as those who did not have either allele or haplotype, providing 
      the first empirical evidence that HLA associations may explain some of the 
      well-established relationship between family history and NHL risk.
FAU - Wang, Sophia S
AU  - Wang SS
AD  - Division of Cancer Etiology, Department of Population Sciences, Beckman Research 
      Institute and City of Hope, Duarte, California, United States of America. 
      sowang@coh.org
FAU - Lu, Yani
AU  - Lu Y
FAU - Rothman, Nathaniel
AU  - Rothman N
FAU - Abdou, Amr M
AU  - Abdou AM
FAU - Cerhan, James R
AU  - Cerhan JR
FAU - De Roos, Anneclaire
AU  - De Roos A
FAU - Davis, Scott
AU  - Davis S
FAU - Severson, Richard K
AU  - Severson RK
FAU - Cozen, Wendy
AU  - Cozen W
FAU - Chanock, Stephen J
AU  - Chanock SJ
FAU - Bernstein, Leslie
AU  - Bernstein L
FAU - Morton, Lindsay M
AU  - Morton LM
FAU - Hartge, Patricia
AU  - Hartge P
LA  - eng
GR  - N01 PC067010/PC/NCI NIH HHS/United States
GR  - N01 PC067008/PC/NCI NIH HHS/United States
GR  - N01-PC-67009/PC/NCI NIH HHS/United States
GR  - N01 PC065064/PC/NCI NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - HHSN261200800001C/RC/CCR NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
GR  - N01 PC067009/CN/NCI NIH HHS/United States
GR  - N02-PC-71105/PC/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20111109
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Confidence Intervals
MH  - Female
MH  - Genotype
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Lymphoma, Non-Hodgkin/*genetics
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Young Adult
PMC - PMC3212525
COIS- Competing Interests: The authors have read the journal's policy and have the 
      following conflicts: Co-author completed part of this study while employed at 
      SAIC Frederick Inc. There are no patents, products in development or marketed 
      products to declare. This does not alter the authors' adherence to all the PLoS 
      ONE policies on sharing data and materials, as detailed online in the guide for 
      authors.
EDAT- 2011/11/19 06:00
MHDA- 2012/04/11 06:00
PMCR- 2011/11/09
CRDT- 2011/11/19 06:00
PHST- 2011/07/06 00:00 [received]
PHST- 2011/10/06 00:00 [accepted]
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/04/11 06:00 [medline]
PHST- 2011/11/09 00:00 [pmc-release]
AID - PONE-D-11-12868 [pii]
AID - 10.1371/journal.pone.0026949 [doi]
PST - ppublish
SO  - PLoS One. 2011;6(11):e26949. doi: 10.1371/journal.pone.0026949. Epub 2011 Nov 9.