PMID- 22096618
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140408
LR  - 20240323
IS  - 2073-4425 (Print)
IS  - 2073-4425 (Electronic)
IS  - 2073-4425 (Linking)
VI  - 2
IP  - 3
DP  - 2011 Sep 1
TI  - Delineating chromosomal breakpoints in radiation-induced papillary thyroid 
      cancer.
PG  - 397-419
LID - 10.3390/genes2030397 [doi]
AB  - Recurrent translocations are well known hallmarks of many human solid tumors and 
      hematological disorders, where patient- and breakpoint-specific information may 
      facilitate prognostication and individualized therapy. In thyroid carcinomas, the 
      proto-oncogenes RET and NTRK1 are often found to be activated through chromosomal 
      rearrangements. However, many sporadic tumors and papillary thyroid carcinomas 
      (PTCs) arising in patients with a history of exposure to elevated levels of 
      ionizing irradiation do not carry these known abnormalities. We developed a rapid 
      scheme to screen tumor cell metaphase spreads and identify candidate genes of 
      tumorigenesis and neoplastic progression for subsequent functional studies. Using 
      a series of overnight fluorescence in situ hybridization (FISH) experiments with 
      pools comprised of bacterial artificial chromosome (BAC) clones, it now becomes 
      possible to rapidly refine breakpoint maps and, within one week, progress from 
      the low resolution Spectral Karyotyping (SKY) maps or Giemsa-banding (G-banding) 
      karyotypes to fully integrated, high resolution physical maps including a list of 
      candiate genes in the critical regions.
FAU - Weier, Heinz-Ulrich G
AU  - Weier HU
AD  - Life Sciences Division, E.O. Lawrence Berkeley National Laboratory, 1 Cyclotron 
      Road, Berkeley, CA 94720, USA.
FAU - Ito, Yuko
AU  - Ito Y
FAU - Kwan, Johnson
AU  - Kwan J
FAU - Smida, Jan
AU  - Smida J
FAU - Weier, Jingly F
AU  - Weier JF
FAU - Hieber, Ludwig
AU  - Hieber L
FAU - Lu, Chun-Mei
AU  - Lu CM
FAU - Lehmann, Lars
AU  - Lehmann L
FAU - Wang, Mei
AU  - Wang M
FAU - Kassabian, Haig J
AU  - Kassabian HJ
FAU - Zeng, Hui
AU  - Zeng H
FAU - O'Brien, Benjamin
AU  - O'Brien B
LA  - eng
GR  - R21 CA123370-02/CA/NCI NIH HHS/United States
GR  - R01 CA136685/CA/NCI NIH HHS/United States
GR  - R21 CA132815-02/CA/NCI NIH HHS/United States
GR  - K25 HD041425/HD/NICHD NIH HHS/United States
GR  - R21 CA132815/CA/NCI NIH HHS/United States
GR  - R21 CA123370/CA/NCI NIH HHS/United States
GR  - R01 HD045736/HD/NICHD NIH HHS/United States
GR  - R01 CA136685-03/CA/NCI NIH HHS/United States
GR  - Wellcome Trust/United Kingdom
GR  - R01 HD045736-03/HD/NICHD NIH HHS/United States
GR  - K25 HD041425-05/HD/NICHD NIH HHS/United States
PT  - Journal Article
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
PMC - PMC3216054
MID - NIHMS326596
EDAT- 2011/11/19 06:00
MHDA- 2011/11/19 06:01
PMCR- 2011/09/01
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2011/11/19 06:01 [medline]
PHST- 2011/09/01 00:00 [pmc-release]
AID - genes-02-00397 [pii]
AID - 10.3390/genes2030397 [doi]
PST - ppublish
SO  - Genes (Basel). 2011 Sep 1;2(3):397-419. doi: 10.3390/genes2030397.