PMID- 22097939
OWN - NLM
STAT- MEDLINE
DCOM- 20120309
LR  - 20111121
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 26
IP  - 12
DP  - 2011 Dec
TI  - Hepatitis C recurrence after liver transplantation: has the human leukocyte 
      antigen mismatching at individual loci a role?
PG  - 1772-8
LID - 10.1111/j.1440-1746.2011.06772.x [doi]
AB  - BACKGROUND AND AIM: The objective of this 11-year cohort retrospective study 
      conducted in adult patients with chronic hepatitis C virus (HCV) who underwent 
      liver transplantation (LT) was to identify whether human leukocyte antigen (HLA) 
      mismatching is associated with the recurrence of HCV and with the time to 
      recurrence of HCV. METHODS: Among the 181 patients (74% men; mean age: 54 years, 
      range 25-71) who underwent a LT between 1995 and 2006 in the study center, 163 
      had relevant data in their medical chart documenting HCV recurrence, and 107 
      (65.64%) reported a histological evidence of HCV recurrence. RESULTS: Survival 
      was 78% at 5 years. There was no significant relationship between the total score 
      of HLA-mismatches and the recurrence of HCV. Similarly, there was no significant 
      relationship between the total score of HLA mismatches and the time to recurrence 
      of HCV. For the analyses at each individual locus, a significant relationship 
      between the individual scores of HLA-mismatches and the recurrence of HCV were 
      observed. Out of the 40 patients who experienced a rejection, the rate of 
      recurrence was not different according to the severity of the rejection (75% 
      mild, 64% moderate and 64% for severe rejection). CONCLUSIONS: In conclusion, 
      this large study did not demonstrate any relationship between the total score of 
      HLA mismatches and HCV-recurrence. Contrarily a significant relationship between 
      the individual scores of HLA mismatches (HLA-A3, HLA-B35, HLA-DR3, HLA-DR7, 
      HLA-DQ2, HLA-DQ2-0) and the recurrence of HCV were observed.
CI  - (c) 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell 
      Publishing Asia Pty Ltd.
FAU - Audet, Maxime
AU  - Audet M
AD  - Department of Surgery, Multivisceral Transplant Centre, Hopital Hautepierre, 
      University of Strasbourg, Strasbourg, France.
FAU - Piardi, Tullio
AU  - Piardi T
FAU - Cag, Murat
AU  - Cag M
FAU - Navarro, Francis
AU  - Navarro F
FAU - Ornis, Sara
AU  - Ornis S
FAU - Cinqualbre, Jacques
AU  - Cinqualbre J
FAU - Wolf, Philippe
AU  - Wolf P
FAU - Panaro, Fabrizio
AU  - Panaro F
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - HLA Antigens/*genetics
MH  - Hepatitis C/*genetics/*therapy
MH  - Histocompatibility/*genetics
MH  - Humans
MH  - *Liver Transplantation
MH  - Male
MH  - Middle Aged
MH  - Recurrence
MH  - Retrospective Studies
EDAT- 2011/11/22 06:00
MHDA- 2012/03/10 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2012/03/10 06:00 [medline]
AID - 10.1111/j.1440-1746.2011.06772.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2011 Dec;26(12):1772-8. doi: 
      10.1111/j.1440-1746.2011.06772.x.