PMID- 22098021
OWN - NLM
STAT- MEDLINE
DCOM- 20120605
LR  - 20131121
IS  - 1944-0057 (Electronic)
IS  - 1944-0057 (Linking)
VI  - 29
IP  - 2
DP  - 2012
TI  - Residues of sulfadiazine and doxycycline in broiler liver and muscle tissue due 
      to cross-contamination of feed.
PG  - 180-8
LID - 10.1080/19440049.2011.631194 [doi]
AB  - Veterinary drugs, such as antimicrobial compounds, are widely used in poultry and 
      may lead to the presence of residues in matrices of animal origin, such as muscle 
      and liver tissue. In this study, broilers received an experimental feed 
      containing sulfadiazine or doxycycline at cross-contamination levels of 2.5, 5 
      and 10% of the therapeutic dose in feed. Breast and thigh muscle and liver 
      samples were collected during treatment and depletion period and analysed via 
      liquid chromatography-tandem mass spectrometry (LC-MS/MS). Concentrations reached 
      a plateau phase 3-5 days after the start of experimental feeding. A rapid 
      depletion of residues was noted after withdrawal of the experimental feed. No 
      significant differences in measured concentrations were observed between the 
      various muscle types. Residue concentrations for some experimental groups; the 
      10% group of sulfadiazine and the 5 and 10% group of doxycycline, however, 
      exceeded their corresponding maximum residue limits (MRLs).
FAU - Vandenberge, V
AU  - Vandenberge V
AD  - Technology and Food Science Unit, Institute for Agricultural and Fisheries 
      Research, Melle, Belgium. valerie.vandenberge@ilvo.vlaanderen.be
FAU - Delezie, E
AU  - Delezie E
FAU - Huyghebaert, G
AU  - Huyghebaert G
FAU - Delahaut, P
AU  - Delahaut P
FAU - Daeseleire, E
AU  - Daeseleire E
FAU - Croubels, S
AU  - Croubels S
LA  - eng
PT  - Journal Article
DEP - 20111121
PL  - England
TA  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess
JT  - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & 
      risk assessment
JID - 101485040
RN  - 0 (Anti-Bacterial Agents)
RN  - 0N7609K889 (Sulfadiazine)
RN  - N12000U13O (Doxycycline)
SB  - IM
MH  - Aging
MH  - Animal Feed/*analysis
MH  - Animals
MH  - Anti-Bacterial Agents/chemistry/metabolism
MH  - *Chickens
MH  - Chromatography, Liquid
MH  - Dose-Response Relationship, Drug
MH  - Doxycycline/*chemistry/metabolism
MH  - Drug Residues/*analysis
MH  - Food Contamination/analysis
MH  - Liver/*chemistry
MH  - Muscle, Skeletal/chemistry
MH  - Sulfadiazine/*chemistry/metabolism
MH  - Tandem Mass Spectrometry
EDAT- 2011/11/22 06:00
MHDA- 2012/06/06 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2012/06/06 06:00 [medline]
AID - 10.1080/19440049.2011.631194 [doi]
PST - ppublish
SO  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012;29(2):180-8. 
      doi: 10.1080/19440049.2011.631194. Epub 2011 Nov 21.