PMID- 22098104
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20220408
IS  - 1442-2050 (Electronic)
IS  - 1120-8694 (Linking)
VI  - 25
IP  - 6
DP  - 2012 Aug
TI  - Clinicopathological and prognostic role of cyclin D1 in esophageal squamous cell 
      carcinoma: a meta-analysis.
PG  - 520-6
LID - 10.1111/j.1442-2050.2011.01278.x [doi]
AB  - Cyclin D1 is one of the most commonly over-expressed oncogenes; however, its role 
      in esophageal squamous cell carcinoma (ESCC) remains controversial. We conducted 
      a meta-analysis of 20 studies, comprising 2,041 patients to clarify this issue. 
      In all studies, paraffin-embedded surgical specimens were collected and the 
      status of cyclin D1 was determined by immunohistochemistry (IHC). The combined 
      odds ratios (Ors) for cyclin D1 expression were 0.74 (95% confidence interval 
      [CI]: 0.58-0.93) for well and moderately differentiated versus poorly 
      differentiated tumors, 0.65 (95% CI: 0.45-0.94) for T1/T2 versus T3/ T4 tumors, 
      0.59 (95% CI: 0.39-0.90) for N0 versus N1 tumors, and 0.48 (95% CI: 0.33-0.71) 
      for stage I/II versus stage III/IV diseases, respectively. The association 
      between cyclin D1 expression and prognosis was examined in 10 studies, and the 
      combined hazard ratio was 1.78 (95% CI: 1.49-2.12). Cyclin D1 expression level 
      detected by IHC is associated with worst clinicopathological features and 
      prognosis for ESCC.
CI  - (c) 2011 Copyright the Authors. Journal compilation (c) 2011, Wiley Periodicals, Inc. 
      and the International Society for Diseases of the Esophagus.
FAU - Zhao, J
AU  - Zhao J
AD  - The Third Affiliated Hospital of Guangzhou Medical College, Department of 
      Cardiothoracic Surgery, Guangzhou, China.
FAU - Li, L
AU  - Li L
FAU - Wei, S
AU  - Wei S
FAU - Gao, Y
AU  - Gao Y
FAU - Chen, Y
AU  - Chen Y
FAU - Wang, G
AU  - Wang G
FAU - Wu, Z
AU  - Wu Z
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20111118
PL  - United States
TA  - Dis Esophagus
JT  - Diseases of the esophagus : official journal of the International Society for 
      Diseases of the Esophagus
JID - 8809160
RN  - 0 (CCND1 protein, human)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism
MH  - Cyclin D1/*metabolism
MH  - Esophageal Neoplasms/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Odds Ratio
MH  - Prognosis
EDAT- 2011/11/22 06:00
MHDA- 2013/01/08 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 10.1111/j.1442-2050.2011.01278.x [doi]
PST - ppublish
SO  - Dis Esophagus. 2012 Aug;25(6):520-6. doi: 10.1111/j.1442-2050.2011.01278.x. Epub 
      2011 Nov 18.