PMID- 22098190
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20120514
IS  - 1365-2362 (Electronic)
IS  - 0014-2972 (Linking)
VI  - 42
IP  - 6
DP  - 2012 Jun
TI  - The molecular pathogenesis of corticotroph tumours.
PG  - 665-76
LID - 10.1111/j.1365-2362.2011.02621.x [doi]
AB  - BACKGROUND: The pathogenesis of tumour formation in the anterior pituitary 
      including adrenocorticotropic hormone (ACTH)-secreting tumours has been 
      intensively studied, but the causative mechanisms involved in pituitary cell 
      transformation and tumourigenesis remain unclear. MATERIALS AND METHODS: We 
      searched PubMed on any paper related with molecular pathology of pituitary 
      corticotroph adenomas and have included to this review all relevant references 
      published up to June 2011. RESULTS: Current studies increased our knowledge on 
      the genetic basis of McCune-Albright syndrome (MAS), multiple endocrine neoplasia 
      type 1 (MEN1), Carney complex (CNC), pituitary adenoma predisposition syndromes 
      and tuberous sclerosis, but they have performed little to elucidate the causes of 
      sporadic pituitary tumours including Cushing disease. DISCUSSION: The aim of this 
      review was to focus on the most recently published advances in the molecular 
      pathology of corticotroph adenomas, which are presented in the context of changes 
      seen in all types of pituitary adenomas, as well as in terms of 
      corticotrophin-releasing hormone/ACTH/cortisol-specific pathways. CONCLUSIONS: We 
      would expect that over the next 5 years, more detailed analysis of inter-cellular 
      communication pathways between pituitary cells, including the cadherins and 
      integrins, and their interactions with other signalling pathways such as the 
      beta-catenin cascade will help elucidate what exactly goes awry in the formation of 
      a benign corticotroph adenoma. This should in turn predict novel forms of 
      pharmacological tumour control.
CI  - (c) 2011 The Authors. European Journal of Clinical Investigation (c) 2011 Stichting 
      European Society for Clinical Investigation Journal Foundation.
FAU - Dworakowska, Dorota
AU  - Dworakowska D
AD  - Department of Endocrinology, Kings College Hospital, Denmark Hill, London, UK.
FAU - Grossman, Ashley B
AU  - Grossman AB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111119
PL  - England
TA  - Eur J Clin Invest
JT  - European journal of clinical investigation
JID - 0245331
SB  - IM
MH  - ACTH-Secreting Pituitary Adenoma/*etiology/metabolism
MH  - Adenoma/*etiology/metabolism
MH  - Corticotrophs/*metabolism
MH  - Humans
MH  - Pituitary ACTH Hypersecretion/*etiology/metabolism
MH  - Signal Transduction/physiology
EDAT- 2011/11/22 06:00
MHDA- 2012/09/28 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
AID - 10.1111/j.1365-2362.2011.02621.x [doi]
PST - ppublish
SO  - Eur J Clin Invest. 2012 Jun;42(6):665-76. doi: 10.1111/j.1365-2362.2011.02621.x. 
      Epub 2011 Nov 19.