PMID- 22098387
OWN - NLM
STAT- MEDLINE
DCOM- 20120921
LR  - 20221207
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 27
IP  - 5
DP  - 2012 May
TI  - High-dose esomeprazole is required for intraesophageal acid control in 
      gastroesophageal reflux disease patients with hiatus hernia.
PG  - 893-8
LID - 10.1111/j.1440-1746.2011.06969.x [doi]
AB  - BACKGROUND AND AIM: The aim of this study was to assess whether the efficacy of 
      proton pump inhibitors (PPI) therapy at a standard dose in esophageal acid 
      control is affected by the presence of hiatus hernia in Chinese gastroesophageal 
      reflux disease patients, and whether a higher dose of PPI is required for acid 
      control. METHODS: Consecutive gastroesophageal reflux disease patients who had 
      typical reflux symptoms and abnormal baseline 24-h esophageal pH and underwent 
      upper endoscopy were enrolled to receive esomeprazole at 40 mg once daily for 4 
      weeks. Patients underwent the dual-channel 24-h pH test at the end of 4-week 
      therapy. If the 24-h esophageal pH was still abnormal at the end of 4-week 
      therapy, then esomeprazole at 40 mg twice daily was given for another 4 weeks 
      after a washout interval of 1 week, and a 24-h pH test was repeated at the end of 
      the therapy. RESULTS: Overall, 76 patients were included, 13 with hiatus hernia. 
      Of the 76 patients treated with a 40 mg of esomeprazole daily, esophageal acid 
      exposure was normalized in 64 (84.2%). Normalization of acid exposure was 
      achieved by standard PPI therapy in 53.2% (7/13) of patients with hiatus hernia 
      and 90.5% (57/63) of those without (P = 0.004). A double dose of esomeprazole was 
      successful in normalizing the esophageal pH in all 12 non-responders to the 
      standard dose of esomeprazole, including the six patients with hiatus hernia and 
      six patients without. CONCLUSIONS: The standard-dose of esomeprazole fails to 
      normalize the esophageal pH in almost 50% of patients with hiatus hernia, in whom 
      the "double-dose" esomeprazole therapy is required.
CI  - (c) 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell 
      Publishing Asia Pty Ltd.
FAU - Peng, Sui
AU  - Peng S
AD  - Division of Gastroenterology & Hepatology, The First Affiliated Hospital of Sun 
      Yat-Sen University, Guangzhou, China.
FAU - Xiao, Ying-Lian
AU  - Xiao YL
FAU - Cui, Yi
AU  - Cui Y
FAU - Lin, Jin-Kun
AU  - Lin JK
FAU - Zhang, Ning
AU  - Zhang N
FAU - Hu, Pin-Jin
AU  - Hu PJ
FAU - Chen, Min-Hu
AU  - Chen MH
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (Proton Pump Inhibitors)
RN  - N3PA6559FT (Esomeprazole)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Asian People
MH  - Chi-Square Distribution
MH  - China
MH  - Esomeprazole/*administration & dosage
MH  - Esophageal pH Monitoring
MH  - Female
MH  - Gastroesophageal Reflux/*complications/*drug therapy
MH  - Gastroscopy
MH  - Hernia, Hiatal/*complications
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*administration & dosage
MH  - Statistics, Nonparametric
MH  - Time Factors
EDAT- 2011/11/22 06:00
MHDA- 2012/09/22 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2012/09/22 06:00 [medline]
AID - 10.1111/j.1440-1746.2011.06969.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2012 May;27(5):893-8. doi: 
      10.1111/j.1440-1746.2011.06969.x.