PMID- 22099329
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20220408
IS  - 1476-7120 (Electronic)
IS  - 1476-7120 (Linking)
VI  - 9
DP  - 2011 Nov 18
TI  - Left atrial volume predicts adverse cardiac and cerebrovascular events in 
      patients with hypertrophic cardiomyopathy.
PG  - 34
LID - 10.1186/1476-7120-9-34 [doi]
AB  - AIMS: To prospectively evaluate the relationship between left atrial volume (LAV) 
      and the risk of clinical events in patients with hypertrophic cardiomyopathy 
      (HCM). METHODS: We enrolled a total of 141 HCM patients with sinus rhythm and 
      normal pump function, and 102 patients (73 men; mean age, 61+/-13 years) who met 
      inclusion criteria were followed for 30.8+/-10.0 months. The patients were divided 
      into two groups with or without major adverse cardiac and cerebrovascular events 
      (MACCE), a composite of stroke, sudden death, and congestive heart failure. 
      Detailed clinical and echocardiographic data were obtained. RESULTS: MACCE 
      occurred in 24 patients (18 strokes, 4 congestive heart failure and 2 sudden 
      deaths). Maximum LAV, minimum LAV, and LAV index (LAVI) corrected for body 
      surface area (BSA) were significantly greater in patients with MACCE than those 
      without MACCE (maximum LAV: 64.3+/-25.0 vs. 51.9+/-16.0 ml, p=0.005; minimum LAV: 
      33.9+/-15.1 vs. 26.2+/-10.9 ml, p=0.008; LAVI: 40.1+/-15.4 vs. 31.5+/-8.7 ml/mm2, 
      p=0.0009), while there were no differences in the other echocardiographic 
      parameters.LAV/BSA of >/=40.4 ml/m2 to identify patients with cardiovascular 
      complications with a sensitivity of 73% and a specificity of 88%. CONCLUSION: 
      LAVI may be an effective marker for detecting the risk of MACCE in patients with 
      HCM and normal pump function.
FAU - Tani, Tomoko
AU  - Tani T
AD  - Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, 
      2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. tomokot@kcho.jp
FAU - Yagi, Toshikazu
AU  - Yagi T
FAU - Kitai, Takeshi
AU  - Kitai T
FAU - Kim, Kitae
AU  - Kim K
FAU - Nakamura, Hitomi
AU  - Nakamura H
FAU - Konda, Toshiko
AU  - Konda T
FAU - Fujii, Yoko
AU  - Fujii Y
FAU - Kawai, Junichi
AU  - Kawai J
FAU - Kobori, Atsushi
AU  - Kobori A
FAU - Ehara, Natsuhiko
AU  - Ehara N
FAU - Kinoshita, Makoto
AU  - Kinoshita M
FAU - Kaji, Shuichiro
AU  - Kaji S
FAU - Yamamuro, Atsushi
AU  - Yamamuro A
FAU - Morioka, Shigefumi
AU  - Morioka S
FAU - Kita, Toru
AU  - Kita T
FAU - Furukawa, Yutaka
AU  - Furukawa Y
LA  - eng
PT  - Journal Article
DEP - 20111118
PL  - England
TA  - Cardiovasc Ultrasound
JT  - Cardiovascular ultrasound
JID - 101159952
SB  - IM
MH  - Atrial Fibrillation/*diagnostic imaging/*epidemiology
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging/*epidemiology
MH  - Cerebrovascular Disorders/*diagnostic imaging/*epidemiology
MH  - Comorbidity
MH  - Echocardiography/statistics & numerical data
MH  - Female
MH  - Heart Atria/*diagnostic imaging
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Organ Size
MH  - Prevalence
MH  - Prognosis
MH  - Risk Assessment
MH  - Risk Factors
PMC - PMC3229541
EDAT- 2011/11/22 06:00
MHDA- 2012/03/20 06:00
PMCR- 2011/11/18
CRDT- 2011/11/22 06:00
PHST- 2011/09/26 00:00 [received]
PHST- 2011/11/18 00:00 [accepted]
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
PHST- 2011/11/18 00:00 [pmc-release]
AID - 1476-7120-9-34 [pii]
AID - 10.1186/1476-7120-9-34 [doi]
PST - epublish
SO  - Cardiovasc Ultrasound. 2011 Nov 18;9:34. doi: 10.1186/1476-7120-9-34.