PMID- 22099464
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20220309
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 72
IP  - 4
DP  - 2011 Nov 17
TI  - Bidirectional regulation of dendritic voltage-gated potassium channels by the 
      fragile X mental retardation protein.
PG  - 630-42
LID - 10.1016/j.neuron.2011.09.033 [doi]
AB  - How transmitter receptors modulate neuronal signaling by regulating voltage-gated 
      ion channel expression remains an open question. Here we report dendritic 
      localization of mRNA of Kv4.2 voltage-gated potassium channel, which regulates 
      synaptic plasticity, and its local translational regulation by fragile X mental 
      retardation protein (FMRP) linked to fragile X syndrome (FXS), the most common 
      heritable mental retardation. FMRP suppression of Kv4.2 is revealed by elevation 
      of Kv4.2 in neurons from fmr1 knockout (KO) mice and in neurons expressing 
      Kv4.2-3'UTR that binds FMRP. Moreover, treating hippocampal slices from fmr1 KO 
      mice with Kv4 channel blocker restores long-term potentiation induced by moderate 
      stimuli. Surprisingly, recovery of Kv4.2 after N-methyl-D-aspartate receptor 
      (NMDAR)-induced degradation also requires FMRP, likely due to NMDAR-induced FMRP 
      dephosphorylation, which turns off FMRP suppression of Kv4.2. Our study of FMRP 
      regulation of Kv4.2 deepens our knowledge of NMDAR signaling and reveals a FMRP 
      target of potential relevance to FXS.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Lee, Hye Young
AU  - Lee HY
AD  - Howard Hughes Medical Institute Departments of Physiology, Biochemistry, and 
      Biophysics, University of California, San Francisco, CA 94158, USA.
FAU - Ge, Woo-Ping
AU  - Ge WP
FAU - Huang, Wendy
AU  - Huang W
FAU - He, Ye
AU  - He Y
FAU - Wang, Gordon X
AU  - Wang GX
FAU - Rowson-Baldwin, Ashley
AU  - Rowson-Baldwin A
FAU - Smith, Stephen J
AU  - Smith SJ
FAU - Jan, Yuh Nung
AU  - Jan YN
FAU - Jan, Lily Yeh
AU  - Jan LY
LA  - eng
GR  - R01 NS069229/NS/NINDS NIH HHS/United States
GR  - R01 NS075252/NS/NINDS NIH HHS/United States
GR  - R37 MH065334/MH/NIMH NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Fmr1 protein, mouse)
RN  - 0 (Potassium Channels, Voltage-Gated)
RN  - 0 (Shal Potassium Channels)
RN  - 139135-51-6 (Fragile X Mental Retardation Protein)
SB  - IM
EIN - Neuron. 2011 Dec 22;72(6):1091
MH  - Animals
MH  - Cells, Cultured
MH  - Dendrites/*physiology
MH  - Fragile X Mental Retardation Protein/*physiology
MH  - HEK293 Cells
MH  - Humans
MH  - Long-Term Potentiation/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Potassium Channels, Voltage-Gated/physiology
MH  - Shal Potassium Channels/antagonists & inhibitors/*physiology
PMC - PMC3433402
MID - NIHMS331930
EDAT- 2011/11/22 06:00
MHDA- 2012/01/13 06:00
PMCR- 2012/11/17
CRDT- 2011/11/22 06:00
PHST- 2011/09/02 00:00 [accepted]
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
PHST- 2012/11/17 00:00 [pmc-release]
AID - S0896-6273(11)00887-7 [pii]
AID - 10.1016/j.neuron.2011.09.033 [doi]
PST - ppublish
SO  - Neuron. 2011 Nov 17;72(4):630-42. doi: 10.1016/j.neuron.2011.09.033.