PMID- 22099961
OWN - NLM
STAT- MEDLINE
DCOM- 20130904
LR  - 20200413
IS  - 2589-0409 (Electronic)
IS  - 1110-0362 (Linking)
VI  - 23
IP  - 2
DP  - 2011 Jun
TI  - Geometrical uncertainty margins in 3D conformal radiotherapy in the pediatric age 
      group.
PG  - 55-60
LID - 10.1016/j.jnci.2011.09.001 [doi]
AB  - PURPOSE: To evaluate set-up variation of pediatric patients undergoing 3D 
      conformal radiotherapy (3DCRT) using electronic portal image device (EPID), in an 
      effort to evaluate the adequacy of the planning target volume (PTV) margin 
      employed for the 3DCRT treatment of pediatric patients. MATERIALS AND METHODS: 
      Set-up data was collected from 48 pediatric patients treated with 3DCRTfor head 
      and neck (31 patients), abdomino-pelvic (9 patients) and chest (8 patients) sites 
      during the period between September 2008 and February 2009. A total of 358 images 
      obtained by EPID were analyzed. The mean (M) and standard deviation (SD) for 
      systematic and random errors were calculated and the results were analyzed. 
      RESULTS: All images were studied in anterior and lateral portals. The systematic 
      errors along longitudinal, lateral and vertical directions in all patients showed 
      an M equal to 1.9, 1.6, and 1.6mm with SD of 1.8, 1.4, and 1.8mm, respectively; 
      (head and neck cases: M equal to 1.5, 1.2, and 1.6mm with SD 1.4, 1.2, and 1.8mm; 
      chest cases: M equal to 2.5, 1.8, and 0.8mm with SD 2.7, 1.7, and 1.2mm, 
      abdomino-pelvic cases: M equal to 2.9, 2.8 and 2.3mm with SD 1.6, 1.2, and 
      2.3mm). Similarly, the random errors for all patients showed SD of 1.9, 1.6, and 
      1.8mm, respectively (head and neck cases: SD 1.7, 1.3, and 1.5mm; chest cases: SD 
      1.2, 1.9, and 2.5mm; abdomino-pelvic cases SD 2.5, 2, and 2.4mm, respectively). 
      Using Van Herk's formula the suggested (PTV) margin around the clinical target 
      volume (CTV) of 5.5mm appears to be adequate. CONCLUSION: The ranges of set-up 
      errors are site specific and depends on many factors.
CI  - Copyright (c) 2011. Published by Elsevier B.V.
FAU - Eldebawy, Eman
AU  - Eldebawy E
AD  - Radiation Oncology Department, Children's Cancer Hospital Egypt CCHE, Egypt.
FAU - Attalla, Ehab
AU  - Attalla E
FAU - Eldesoky, Ismail
AU  - Eldesoky I
FAU - Zaghloul, Mohamed S
AU  - Zaghloul MS
LA  - eng
PT  - Journal Article
DEP - 20111010
PL  - England
TA  - J Egypt Natl Canc Inst
JT  - Journal of the Egyptian National Cancer Institute
JID - 9424566
SB  - IM
MH  - Abdominal Neoplasms/*pathology/radiotherapy
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Diagnostic Errors
MH  - Head and Neck Neoplasms/*pathology/radiotherapy
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Imaging, Three-Dimensional/methods
MH  - Pelvic Neoplasms/*pathology/radiotherapy
MH  - *Radiotherapy Planning, Computer-Assisted
MH  - Radiotherapy, Conformal
MH  - Thoracic Neoplasms/*pathology/radiotherapy
EDAT- 2011/11/22 06:00
MHDA- 2013/09/05 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/04/04 00:00 [received]
PHST- 2011/05/30 00:00 [accepted]
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2013/09/05 06:00 [medline]
AID - S1110-0362(11)00009-4 [pii]
AID - 10.1016/j.jnci.2011.09.001 [doi]
PST - ppublish
SO  - J Egypt Natl Canc Inst. 2011 Jun;23(2):55-60. doi: 10.1016/j.jnci.2011.09.001. 
      Epub 2011 Oct 10.