PMID- 22101578
OWN - NLM
STAT- MEDLINE
DCOM- 20121019
LR  - 20151119
IS  - 2042-7670 (Electronic)
IS  - 0042-4900 (Linking)
VI  - 170
IP  - 1
DP  - 2012 Jan 7
TI  - Acute phase proteins as a tool for differential diagnosis of wasting diseases in 
      growing pigs.
PG  - 21
LID - 10.1136/vr.100005 [doi]
AB  - The concentrations of haptoglobin (Hp), C-reactive protein (CRP) and serum 
      amyloid A (SAA) were measured in wasted pigs, first to evaluate their usefulness 
      in the diagnosis of infectious, wasting diseases in pigs, and second, to evaluate 
      whether their concentrations can distinguish the lymphoid depletion score in the 
      lymph tissues of wasted affected pigs. Fifty-three wasted pigs and seven specific 
      pathogen free (SPF) pigs were postmortem examined. Gross lesions were evaluated 
      and samples for histopathological, immunohistochemical, molecular biology and 
      microbiological analysis were taken. Thirty-one pigs were diagnosed as 
      postweaning multisystemic wasting syndrome (PMWS) and 22 as porcine respiratory 
      disease complex (PRDC). Lymphoid depletion degree in lymph tissues of PMWS and 
      PRDC affected pigs was determined. Serum Hp was significantly higher in pigs with 
      PRDC in comparison with the PMWS affected pigs. Serum CRP concentration was 
      significantly lower in pigs with PRDC than in PMWS affected pigs (P<0.001). CRP 
      and SAA levels increased with the lymphoid depletion score, presenting 
      statistical differences between pigs with no depletion and pigs with low, 
      moderate or severe lymphoid depletion (P<0.05, P<0.05 and P<0.001 for CRP and 
      P<0.01, P<0.01 and P<0.01 for SAA, respectively). Hp was higher in pigs with no 
      or low depletion compared with the pigs suffering severe lymphoid depletion 
      (P<0.001 and P<0.05, respectively).
FAU - Quereda, J J
AU  - Quereda JJ
AD  - Departamento de Produccion Animal, Facultad de Veterinaria, Universidad de 
      Murcia, 30100 Murcia, Spain. jjquere@um.es
FAU - Gomez, S
AU  - Gomez S
FAU - Seva, J
AU  - Seva J
FAU - Ramis, G
AU  - Ramis G
FAU - Ceron, J J
AU  - Ceron JJ
FAU - Munoz, A
AU  - Munoz A
FAU - Pallares, F J
AU  - Pallares FJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111118
PL  - England
TA  - Vet Rec
JT  - The Veterinary record
JID - 0031164
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (Haptoglobins)
RN  - 0 (Serum Amyloid A Protein)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Acute-Phase Proteins/*metabolism
MH  - Animals
MH  - Biomarkers/metabolism
MH  - C-Reactive Protein/metabolism
MH  - Diagnosis, Differential
MH  - Female
MH  - Haptoglobins/metabolism
MH  - Lymph Nodes/pathology
MH  - Male
MH  - Porcine Postweaning Multisystemic Wasting Syndrome/*blood/diagnosis
MH  - Porcine Reproductive and Respiratory Syndrome/*blood/diagnosis
MH  - Serum Amyloid A Protein/metabolism
MH  - Severity of Illness Index
MH  - Swine
MH  - Swine Diseases/*blood/diagnosis
MH  - Wasting Syndrome/blood/diagnosis/*veterinary
EDAT- 2011/11/22 06:00
MHDA- 2012/10/20 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2012/10/20 06:00 [medline]
AID - vr.100005 [pii]
AID - 10.1136/vr.100005 [doi]
PST - ppublish
SO  - Vet Rec. 2012 Jan 7;170(1):21. doi: 10.1136/vr.100005. Epub 2011 Nov 18.