PMID- 22101740
OWN - NLM
STAT- MEDLINE
DCOM- 20130411
LR  - 20211021
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 47
IP  - 3
DP  - 2012 Jul
TI  - Effect of valproic acid through regulation of NMDA receptor-ERK signaling in 
      sleep deprivation rats.
PG  - 554-8
LID - 10.1007/s12031-011-9673-5 [doi]
AB  - Although the effect of mood stabilizer valproic acid (VPA) through multiple 
      signaling pathways has been shown, its therapeutic mechanism is still largely 
      unknown. We investigated the effect of VPA (200 mg/kg, every 12 h) in sleep 
      deprivation (SD) rats (72 h), the manic-like animal model, focusing on the 
      N-methyl-D: -aspartic acid (NMDA) receptor and signaling mediators of synaptic 
      plasticity such as extracellular signal-regulated protein kinase (ERK), cAMP 
      response element-binding protein (CREB), B cell chronic lymphocytic 
      leukemia/lymphoma 2 (BCL2), and brain-derived neurotrophic factor (BDNF). SD 
      reduced the expression of the NR2B subunit of the NMDA receptor in the frontal 
      cortex and hippocampus but did not affect the expression of NR1 and NR2A 
      subunits. In comparison, VPA inhibited the SD-induced reduction of NR2B 
      expression in both brain regions. In addition, SD attenuated ERK phosphorylation 
      in the frontal cortex and hippocampus, whereas VPA prevented the attenuation. VPA 
      also protected the SD-induced decrease of CREB phosphorylation, BCL2 expression, 
      and BDNF expression in the frontal cortex but not in the hippocampus. These 
      results indicate that VPA could regulate NMDA receptor-ERK signaling in SD rats, 
      preventing the SD-induced decrease of the expression of NR2B subunit and the 
      activation of ERK signaling mediators such as ERK, CREB, BCL2, and BDNF.
FAU - Park, Hae Jeong
AU  - Park HJ
AD  - Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, 
      Seoul, 130-701, Republic of Korea.
FAU - Kang, Won Sub
AU  - Kang WS
FAU - Paik, Jong Woo
AU  - Paik JW
FAU - Kim, Jong Woo
AU  - Kim JW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111119
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Antimanic Agents)
RN  - 0 (NR2B NMDA receptor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 614OI1Z5WI (Valproic Acid)
SB  - IM
MH  - Animals
MH  - Antimanic Agents/pharmacology
MH  - Frontal Lobe/*drug effects/metabolism
MH  - Hippocampus/*drug effects/metabolism
MH  - MAP Kinase Signaling System/*drug effects/physiology
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Sleep Deprivation/*physiopathology
MH  - Valproic Acid/*pharmacology
EDAT- 2011/11/22 06:00
MHDA- 2013/04/12 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/09/22 00:00 [received]
PHST- 2011/11/07 00:00 [accepted]
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2013/04/12 06:00 [medline]
AID - 10.1007/s12031-011-9673-5 [doi]
PST - ppublish
SO  - J Mol Neurosci. 2012 Jul;47(3):554-8. doi: 10.1007/s12031-011-9673-5. Epub 2011 
      Nov 19.