PMID- 22105492
OWN - NLM
STAT- MEDLINE
DCOM- 20120925
LR  - 20211021
IS  - 1432-1971 (Electronic)
IS  - 0172-0643 (Linking)
VI  - 33
IP  - 4
DP  - 2012 Apr
TI  - Assessment of risk factors for Korean children with Kawasaki disease.
PG  - 513-20
LID - 10.1007/s00246-011-0143-1 [doi]
AB  - Kawasaki disease (KD) is the most common cause of acquired heart disease in 
      children. Intravenous immunoglobulin (IVIG) is the standard therapy for KD, but 
      more than 10% of KD patients do not respond to IVIG and are at high risk for the 
      development of coronary artery lesions (CALs). To identify clinical and genetic 
      risk factors associated with CAL development and IVIG nonresponsiveness, this 
      study analyzed the clinical data for 478 Korean KD patients. Multivariate 
      logistic regression analysis showed that incomplete KD, IVIG nonresponse, fever 
      duration of 7 days or longer, and the CC/AC genotypes of the rs7604693 single 
      nucleotide polymorphism (SNP) in the PELI1 gene were significantly associated 
      with the development of CALs, with odds ratios (ORs) ranging from 2.06 to 3.04. 
      The risk of CAL formation was synergistically increased by the addition of 
      individual risk factors, particularly the genetic variant in the PELI1 gene. 
      Multivariate analysis also showed that a serum albumin level of 3.6 g/dl or lower 
      was significantly associated with nonresponsiveness to IVIG [OR, 2.76; 95% 
      confidence interval (CI), 1.34-5.68; P = 0.006]. Conclusively, incomplete KD, 
      IVIG nonresponsiveness, long febrile days, and the rs7604693 genetic variant in 
      the PELI1 gene are major risk factors for the development of CALs, whereas low 
      serum albumin concentration is an independent risk factor for IVIG 
      nonresponsiveness.
FAU - Kim, Jae-Jung
AU  - Kim JJ
AD  - Asan Institute for Life Sciences, University of Ulsan College of Medicine, 388-1 
      Pungnap-2-Dong, Songpa-Gu, Seoul 138-736, Korea.
FAU - Hong, Young Mi
AU  - Hong YM
FAU - Yun, Sin Weon
AU  - Yun SW
FAU - Han, Myung Ki
AU  - Han MK
FAU - Lee, Kyung-Yil
AU  - Lee KY
FAU - Song, Min Seob
AU  - Song MS
FAU - Lee, Hyoung-Doo
AU  - Lee HD
FAU - Kim, Dong Soo
AU  - Kim DS
FAU - Sohn, Sejung
AU  - Sohn S
FAU - Ha, Kee-Soo
AU  - Ha KS
FAU - Hong, Soo-Jong
AU  - Hong SJ
FAU - Kim, Kwi-Joo
AU  - Kim KJ
FAU - Park, In-Sook
AU  - Park IS
FAU - Jang, Gi Young
AU  - Jang GY
FAU - Lee, Jong-Keuk
AU  - Lee JK
CN  - Korean Kawasaki Disease Genetics Consortium
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20111122
PL  - United States
TA  - Pediatr Cardiol
JT  - Pediatric cardiology
JID - 8003849
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunologic Factors)
RN  - 0 (Nuclear Proteins)
RN  - 9007-49-2 (DNA)
RN  - EC 2.3.2.27 (PELI1 protein, human)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Child, Preschool
MH  - Coronary Vessels/*pathology
MH  - DNA/genetics
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Immunoglobulins, Intravenous/administration & dosage/therapeutic use
MH  - Immunologic Factors/administration & dosage/therapeutic use
MH  - Infant
MH  - Infant, Newborn
MH  - Injections, Intravenous
MH  - Male
MH  - Morbidity/trends
MH  - Mucocutaneous Lymph Node Syndrome/drug therapy/*epidemiology/genetics
MH  - Nuclear Proteins/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Republic of Korea/epidemiology
MH  - Retrospective Studies
MH  - Risk Assessment/*methods
MH  - Risk Factors
MH  - Ubiquitin-Protein Ligases/genetics
FIR - Park, In-Sook
IR  - Park IS
FIR - Yoo, Jeong-Jin
IR  - Yoo JJ
FIR - Hong, Soo-Jong
IR  - Hong SJ
FIR - Kim, Kwi-Joo
IR  - Kim KJ
FIR - Lee, Jong-Keuk
IR  - Lee JK
FIR - Kim, Jae-Jung
IR  - Kim JJ
FIR - Park, Young-Mi
IR  - Park YM
FIR - Hong, Young Mi
IR  - Hong YM
FIR - Sohn, Sejung
IR  - Sohn S
FIR - Jang, Gi Young
IR  - Jang GY
FIR - Ha, Kee-Soo
IR  - Ha KS
FIR - Nam, Hyo-Kyoung
IR  - Nam HK
FIR - Byeon, Jung-Hye
IR  - Byeon JH
FIR - Yun, Sin Weon
IR  - Yun SW
FIR - Han, Myung Ki
IR  - Han MK
FIR - Lee, Kyung-Yil
IR  - Lee KY
FIR - Hwang, Ja-Young
IR  - Hwang JY
FIR - Rhim, Jung-Woo
IR  - Rhim JW
FIR - Song, Min Seob
IR  - Song MS
FIR - Lee, Hyoung-Doo
IR  - Lee HD
FIR - Kim, Dong Soo
IR  - Kim DS
FIR - Lee, Jae-Moo
IR  - Lee JM
EDAT- 2011/11/23 06:00
MHDA- 2012/09/26 06:00
CRDT- 2011/11/23 06:00
PHST- 2011/05/28 00:00 [received]
PHST- 2011/11/03 00:00 [accepted]
PHST- 2011/11/23 06:00 [entrez]
PHST- 2011/11/23 06:00 [pubmed]
PHST- 2012/09/26 06:00 [medline]
AID - 10.1007/s00246-011-0143-1 [doi]
PST - ppublish
SO  - Pediatr Cardiol. 2012 Apr;33(4):513-20. doi: 10.1007/s00246-011-0143-1. Epub 2011 
      Nov 22.