PMID- 22105689
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20220317
IS  - 1527-3350 (Electronic)
IS  - 0270-9139 (Linking)
VI  - 55
IP  - 5
DP  - 2012 May
TI  - Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B 
      virus clearance and hepatocellular carcinoma development.
PG  - 1426-31
LID - 10.1002/hep.24799 [doi]
AB  - Recent genome-wide association studies showed that four single-nucleotide 
      polymorphisms (SNPs) in human leukocyte antigen (HLA)-DP (rs3077 and rs9277535) 
      and HLA-DQ (rs2856718 and rs7453920) were associated with chronic hepatitis B 
      virus (HBV) infection in Japanese populations. More than 75% of hepatocellular 
      carcinoma (HCC) patients are attributable to persistent infection of hepatitis B 
      virus (HBV), especially in China. We genotyped these four SNPs in 1,300 
      HBV-positive HCC patients, 1,344 persistent HBV carriers, and 1,344 persons with 
      HBV natural clearance from Southeast China to further test the associations of 
      HLA-DP/DQ variants and with risk of both HBV clearance and HCC development. 
      Logistic regression analyses showed that HLA-DQ rs2856718 significantly decreased 
      host HCC risk, whereas three SNPs were associated with HBV clearance (HLA-DP 
      rs9277535 as well as HLA-DQ rs7453920 and rs2856718). In addition, HLA-DP rs3077 
      showed an approaching significant effect on susceptibility to HBV persistent 
      infection and HCC development when considering multiple testing adjustments. 
      Taken together, we report, for the first time, that genetic variants in the 
      HLA-DP and HLA-DQ loci may be marker SNPs for risk of both HBV clearance and HCC 
      development.
CI  - Copyright (c) 2011 American Association for the Study of Liver Diseases.
FAU - Hu, Lingmin
AU  - Hu L
AD  - Department of Epidemiology and Biostatistics, MOE Key Laboratory of Modern 
      Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China.
FAU - Zhai, Xiangjun
AU  - Zhai X
FAU - Liu, Jibin
AU  - Liu J
FAU - Chu, Minjie
AU  - Chu M
FAU - Pan, Shandong
AU  - Pan S
FAU - Jiang, Jie
AU  - Jiang J
FAU - Zhang, Yixin
AU  - Zhang Y
FAU - Wang, Hua
AU  - Wang H
FAU - Chen, Jianguo
AU  - Chen J
FAU - Shen, Hongbing
AU  - Shen H
FAU - Hu, Zhibin
AU  - Hu Z
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120316
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Biopsy, Needle
MH  - Carcinoma, Hepatocellular/epidemiology/*genetics/virology
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Confidence Intervals
MH  - Female
MH  - Genetic Variation
MH  - Genotype
MH  - HLA-DP Antigens/*genetics
MH  - HLA-DQ Antigens/*genetics
MH  - Hepatitis B virus/*genetics
MH  - Hepatitis B, Chronic/epidemiology/*genetics/physiopathology
MH  - Heterozygote
MH  - Humans
MH  - Immunohistochemistry
MH  - Incidence
MH  - Liver Neoplasms/epidemiology/*genetics/virology
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Sex Distribution
EDAT- 2011/11/23 06:00
MHDA- 2012/06/20 06:00
CRDT- 2011/11/23 06:00
PHST- 2011/08/10 00:00 [received]
PHST- 2011/11/02 00:00 [accepted]
PHST- 2011/11/23 06:00 [entrez]
PHST- 2011/11/23 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - 10.1002/hep.24799 [doi]
PST - ppublish
SO  - Hepatology. 2012 May;55(5):1426-31. doi: 10.1002/hep.24799. Epub 2012 Mar 16.