PMID- 22106821
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20181201
IS  - 1480-3275 (Electronic)
IS  - 0008-4166 (Linking)
VI  - 57
IP  - 12
DP  - 2011 Dec
TI  - Pathogenicity of Ureaplasma urealyticum and Ureaplasma parvum in the lower 
      genital tract of female BALB/c mice.
PG  - 987-92
LID - 10.1139/w11-098 [doi]
AB  - The aim of this study was to establish a murine model of lower genital tract 
      infection by Ureaplasma urealyticum and Ureaplasma parvum and evaluate 
      differences in pathogenicity of five serotypes. BALB/c female mice were divided 
      into seven groups (five mice in each group), including five groups infected in 
      the lower genital tract after treatment with estradiol with U. urealyticum 
      serotypes 4 and 8 and U. parvum serotypes 1, 3, and 6, respectively, and two 
      control groups of untreated mice and estradiol treated mice. The presence of 
      infection was determined on solid and liquid culture media. Tumor necrosis 
      factor-alpha (TNF-alpha) expression in lower genital tract secretions was determined 
      by PCR, and morphological and histological changes of the lower genital tract 
      were observed. The genital secretions of all inoculated mice were positive for U. 
      urealyticum and U. parvum on culture in both liquid and solid media. TNF-alpha 
      expression at 7 and 14 days after infection was markedly increased as compared 
      with that of the controls. Morphological changes of the external genitalia 
      included hair loss and erosions, and histological examination revealed 
      infiltration by inflammatory cells. The five serotypes tested were all found to 
      be pathogenic, and the pathogenicity varied with serotype 4 showing the greatest 
      pathogenicity.
FAU - Zhu, Guo-Xing
AU  - Zhu GX
AD  - Department of Dermatology and Venereology, The Third Affiliated Hospital, Sun 
      Yat-Sen University, Guangzhou 510630, People's Republic of China.
FAU - Lu, Chun
AU  - Lu C
FAU - Chen, Chuan-Jie
AU  - Chen CJ
FAU - Feng, Pei-Ying
AU  - Feng PY
FAU - Ma, Han
AU  - Ma H
FAU - Lu, Rong-Biao
AU  - Lu RB
FAU - Yuan, Ying-Li
AU  - Yuan YL
LA  - eng
PT  - Journal Article
DEP - 20111122
PL  - Canada
TA  - Can J Microbiol
JT  - Canadian journal of microbiology
JID - 0372707
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Bodily Secretions/microbiology
MH  - Disease Models, Animal
MH  - Female
MH  - Gene Expression Regulation
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Polymerase Chain Reaction
MH  - Reproductive Tract Infections/*microbiology/pathology
MH  - Serotyping
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
MH  - Ureaplasma/genetics/*pathogenicity
MH  - Ureaplasma Infections/*microbiology/pathology
MH  - Ureaplasma urealyticum/genetics/*pathogenicity
EDAT- 2011/11/24 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - 10.1139/w11-098 [doi]
PST - ppublish
SO  - Can J Microbiol. 2011 Dec;57(12):987-92. doi: 10.1139/w11-098. Epub 2011 Nov 22.