PMID- 22107069
OWN - NLM
STAT- MEDLINE
DCOM- 20140310
LR  - 20130715
IS  - 1600-0838 (Electronic)
IS  - 0905-7188 (Linking)
VI  - 23
IP  - 4
DP  - 2013 Aug
TI  - Muscle fatigue experienced during maximal eccentric exercise is predictive of the 
      plasma creatine kinase (CK) response.
PG  - 501-7
LID - 10.1111/j.1600-0838.2011.01413.x [doi]
AB  - Unaccustomed eccentric exercise may cause skeletal muscle damage with an increase 
      in plasma creatine kinase (CK) activity. Although the wide variability among 
      individuals in CK response to standardized lengthening contractions has been well 
      described, the reasons underlying this phenomenon have not yet been understood. 
      Therefore, this study investigated a possible correlation of the changes in 
      muscle damage indirect markers after an eccentric exercise with the decline in 
      muscle performance during the exercise. Twenty-seven healthy untrained male 
      subjects performed three sets of 30 maximal isokinetic eccentric contractions of 
      the knee extensors. The muscular work was recorded using an isokinetic 
      dynamometer to assess muscle fatigue by means of various fatigue indices. Plasma 
      CK activity, muscle soreness, and stiffness were measured before (pre) and one 
      day after (post) exercise. The eccentric exercise bout induced significant 
      changes of the three muscle damage indirect markers. Large inter-subject 
      variability was observed for all criteria measured. More interestingly, the log 
      (CK(post) /CK(pre)) and muscle stiffness appeared to be closely correlated with 
      the relative work decrease (r = 0.84, r(2)  = 0.70 and r = 0.75, r(2)  = 0.56, 
      respectively). This is the first study to propose that the muscle fatigue profile 
      during maximal eccentric protocol could predict the magnitude of the symptoms 
      associated with muscle damage in humans.
CI  - (c) 2011 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Hody, S
AU  - Hody S
AD  - GIGA - Neuroscience, University of Liege, Liege, Belgium.
FAU - Rogister, B
AU  - Rogister B
FAU - Leprince, P
AU  - Leprince P
FAU - Wang, F
AU  - Wang F
FAU - Croisier, J-L
AU  - Croisier JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111123
PL  - Denmark
TA  - Scand J Med Sci Sports
JT  - Scandinavian journal of medicine & science in sports
JID - 9111504
RN  - EC 2.7.3.2 (Creatine Kinase)
SB  - IM
MH  - Adult
MH  - Creatine Kinase/*blood
MH  - Exercise/*physiology
MH  - Humans
MH  - Knee Joint/*physiology
MH  - Male
MH  - Muscle Contraction/*physiology
MH  - Muscle Fatigue/*physiology
MH  - Muscle, Skeletal/enzymology/physiology
MH  - Quadriceps Muscle/*enzymology/physiology
MH  - Torque
MH  - Young Adult
OTO - NOTNLM
OT  - creatine kinase activity
OT  - eccentric contraction
OT  - muscle damage
OT  - muscle fatigue
OT  - muscular work
EDAT- 2011/11/24 06:00
MHDA- 2014/03/13 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/09/18 00:00 [accepted]
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
AID - 10.1111/j.1600-0838.2011.01413.x [doi]
PST - ppublish
SO  - Scand J Med Sci Sports. 2013 Aug;23(4):501-7. doi: 
      10.1111/j.1600-0838.2011.01413.x. Epub 2011 Nov 23.