PMID- 22107686
OWN - NLM
STAT- MEDLINE
DCOM- 20140121
LR  - 20111220
IS  - 1873-6254 (Electronic)
IS  - 0001-706X (Linking)
VI  - 121
IP  - 2
DP  - 2012 Feb
TI  - Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, 
      AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax.
PG  - 152-5
LID - 10.1016/j.actatropica.2011.10.009 [doi]
AB  - We evaluated the influence of allelic frequency of the human leukocyte antigen 
      (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite 
      and merozoite peptides in patients with Plasmodium vivax malaria acquired in 
      endemic areas of Brazil. IgG antibodies were detected by enzyme-linked 
      immunosorbent assay against four peptides of circumsporozoite protein (CSP) 
      (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface 
      protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein 
      (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of 
      antibody response to CSP amino terminal, as well as an association between 
      HLA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we 
      suggest a potential regulatory role of the HLA-DRB1 alleles in the production of 
      antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population 
      exposed to malaria.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Storti-Melo, Luciane Moreno
AU  - Storti-Melo LM
AD  - Departamento de Biociencias, Campus Universitario Prof. Alberto Carvalho, 
      Universidade Federal de Sergipe, Itabaiana, SE, Brazil. stortilu@yahoo.com.br
FAU - da Costa, Daniela Reis
AU  - da Costa DR
FAU - Souza-Neiras, Wanessa Christina
AU  - Souza-Neiras WC
FAU - Cassiano, Gustavo Capatti
AU  - Cassiano GC
FAU - Couto, Vanja Suely Calvosa D'Almeida
AU  - Couto VS
FAU - Povoa, Marinete Marins
AU  - Povoa MM
FAU - Soares, Irene da Silva
AU  - Soares Ida S
FAU - de Carvalho, Luzia Helena
AU  - de Carvalho LH
FAU - Arevalo-Herrera, Myrian
AU  - Arevalo-Herrera M
FAU - Herrera, Socrates
AU  - Herrera S
FAU - Rossit, Andrea Regina Baptista
AU  - Rossit AR
FAU - Cordeiro, Jose Antonio
AU  - Cordeiro JA
FAU - de Mattos, Luiz Carlos
AU  - de Mattos LC
FAU - Machado, Ricardo Luiz Dantas
AU  - Machado RL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111104
PL  - Netherlands
TA  - Acta Trop
JT  - Acta tropica
JID - 0370374
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (Antigens, Protozoan)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Alleles
MH  - Antibodies, Protozoan/*blood
MH  - Antigens, Protozoan/*immunology
MH  - Brazil
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Gene Frequency
MH  - HLA-DRB1 Chains/*genetics/immunology
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Malaria, Vivax/*immunology
MH  - Middle Aged
MH  - Plasmodium vivax/*immunology
EDAT- 2011/11/24 06:00
MHDA- 2014/01/22 06:00
CRDT- 2011/11/24 06:00
PHST- 2010/05/27 00:00 [received]
PHST- 2011/09/19 00:00 [revised]
PHST- 2011/10/12 00:00 [accepted]
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2014/01/22 06:00 [medline]
AID - S0001-706X(11)00305-6 [pii]
AID - 10.1016/j.actatropica.2011.10.009 [doi]
PST - ppublish
SO  - Acta Trop. 2012 Feb;121(2):152-5. doi: 10.1016/j.actatropica.2011.10.009. Epub 
      2011 Nov 4.