PMID- 22108236
OWN - NLM
STAT- MEDLINE
DCOM- 20120627
LR  - 20171116
IS  - 1879-0542 (Electronic)
IS  - 0165-2478 (Linking)
VI  - 142
IP  - 1-2
DP  - 2012 Feb 29
TI  - Maturation profiles of peripheral blood dendritic cells in patients with 
      endogenous uveitis.
PG  - 14-9
LID - 10.1016/j.imlet.2011.10.012 [doi]
AB  - To determine whether or not maturation of dendritic cells (DCs) is associated 
      with pathogenesis of endogenous uveitis, we analyzed expression of maturation 
      markers, including CD80, CD86, and human leukocyte antigen (HLA)-DR, in 
      peripheral blood (PB) DCs for comparison between healthy controls (HCs) and 
      uveitis patients. A total of 21 patients and 16 HCs were included. Flow 
      cytometric analysis was performed using PB DCs during the active phase of 
      intraocular inflammation. CD86 and HLA-DR expression was higher in PB DCs from 
      uveitis patients versus HCs, whereas that of CD80 was not significantly 
      different. Levels of CD86 and HLA-DR expression tended to parallel those of 
      inflammatory activity, and decreased after anti-inflammatory therapy. However, 
      expression of CD86 and HLA-DR, even in remission, was not completely 
      down-regulated to the low levels found in HCs. Our results indicate the 
      maturation of DCs may play a role in the pathogenesis of endogenous uveitis. The 
      relatively high expression of HLA-DR and co-stimulatory molecules even in the 
      quiescence of inflammation suggests maturation of DCs may be associated with 
      chronicity and recurrence of uveitis.
CI  - Crown Copyright (c) 2011. Published by Elsevier B.V. All rights reserved.
FAU - Kim, Tae Wan
AU  - Kim TW
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Republic of Korea.
FAU - Kang, Jae Seung
AU  - Kang JS
FAU - Kong, Joo Myoung
AU  - Kong JM
FAU - Bae, Seyeon
AU  - Bae S
FAU - Yu, Yeonsil
AU  - Yu Y
FAU - Chung, Hum
AU  - Chung H
FAU - Yu, Hyeong Gon
AU  - Yu HG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111115
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (B7-1 Antigen)
RN  - 0 (B7-2 Antigen)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - B7-1 Antigen/metabolism
MH  - B7-2 Antigen/metabolism
MH  - Case-Control Studies
MH  - *Cell Differentiation
MH  - Dendritic Cells/*cytology/*immunology/metabolism/pathology
MH  - Female
MH  - Flow Cytometry
MH  - HLA-DR Antigens/metabolism
MH  - Humans
MH  - Inflammation/immunology
MH  - Male
MH  - Middle Aged
MH  - Uveitis/*immunology/physiopathology
EDAT- 2011/11/24 06:00
MHDA- 2012/06/28 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/07/12 00:00 [received]
PHST- 2011/10/19 00:00 [revised]
PHST- 2011/10/31 00:00 [accepted]
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2012/06/28 06:00 [medline]
AID - S0165-2478(11)00254-9 [pii]
AID - 10.1016/j.imlet.2011.10.012 [doi]
PST - ppublish
SO  - Immunol Lett. 2012 Feb 29;142(1-2):14-9. doi: 10.1016/j.imlet.2011.10.012. Epub 
      2011 Nov 15.