PMID- 22108527
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20211021
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 10
DP  - 2011 Nov 22
TI  - Dysglycemia induces abnormal circadian blood pressure variability.
PG  - 104
LID - 10.1186/1475-2840-10-104 [doi]
AB  - BACKGROUND: Prediabetes (PreDM) in asymptomatic adults is associated with 
      abnormal circadian blood pressure variability (abnormal CBPV). HYPOTHESIS: 
      Systemic inflammation and glycemia influence circadian blood pressure 
      variability. METHODS: Dahl salt-sensitive (S) rats (n = 19) after weaning were 
      fed either an American (AD) or a standard (SD) diet. The AD (high-glycemic-index, 
      high-fat) simulated customary human diet, provided daily overabundant calories 
      which over time lead to body weight gain. The SD (low-glycemic-index, low-fat) 
      mirrored desirable balanced human diet for maintaining body weight. Body weight 
      and serum concentrations for fasting glucose (FG), adipokines (leptin and 
      adiponectin), and proinflammatory cytokines [monocyte chemoattractant protein-1 
      (MCP-1) and tumor necrosis factor-alpha (TNF-alpha)] were measured. Rats were surgically 
      implanted with C40 transmitters and blood pressure (BP-both systolic; SBP and 
      diastolic; DBP) and heart rate (HR) were recorded by telemetry every 5 minutes 
      during both sleep (day) and active (night) periods. Pulse pressure (PP) was 
      calculated (PP = SBP-DBP). RESULTS: [mean(SEM)]: The AD fed group displayed 
      significant increase in body weight (after 90 days; p < 0.01). Fasting glucose, 
      adipokine (leptin and adiponectin) concentrations significantly increased (at 90 
      and 172 days; all p < 0.05), along with a trend for increased concentrations of 
      systemic pro-inflammatory cytokines (MCP-1 and TNF-alpha) on day 90. The AD fed 
      group, with significantly higher FG, also exhibited significantly elevated 
      circadian (24-hour) overall mean SBP, DBP, PP and HR (all p < 0.05). CONCLUSION: 
      These data validate our stated hypothesis that systemic inflammation and glycemia 
      influence circadian blood pressure variability. This study, for the first time, 
      demonstrates a cause and effect relationship between caloric excess, enhanced 
      systemic inflammation, dysglycemia, loss of blood pressure control and abnormal 
      CBPV. Our results provide the fundamental basis for examining the relationship 
      between dysglycemia and perturbation of the underlying mechanisms (adipose tissue 
      dysfunction induced local and systemic inflammation, insulin resistance and 
      alteration of adipose tissue precursors for the renin-aldosterone-angiotensin 
      system) which generate abnormal CBPV.
FAU - Kumarasamy, Sivarajan
AU  - Kumarasamy S
AD  - Department of Physiology and Pharmacology, University of Toledo College of 
      Medicine and Life Sciences, Toledo, OH 43614, USA.
FAU - Gopalakrishnan, Kathirvel
AU  - Gopalakrishnan K
FAU - Kim, Dong Hyun
AU  - Kim DH
FAU - Abraham, Nader G
AU  - Abraham NG
FAU - Johnson, William D
AU  - Johnson WD
FAU - Joe, Bina
AU  - Joe B
FAU - Gupta, Alok K
AU  - Gupta AK
LA  - eng
GR  - P01 HL034300/HL/NHLBI NIH HHS/United States
GR  - R01 HL076709/HL/NHLBI NIH HHS/United States
GR  - R01 HL020176/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111122
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
RN  - 0 (Adiponectin)
RN  - 0 (Adipoq protein, rat)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Leptin)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adiponectin/blood
MH  - Animals
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - *Blood Pressure
MH  - Blood Pressure Monitoring, Ambulatory
MH  - Chemokine CCL2/blood
MH  - *Circadian Rhythm
MH  - Diet, High-Fat
MH  - Disease Models, Animal
MH  - Heart Rate
MH  - Inflammation/blood/etiology/*physiopathology
MH  - Inflammation Mediators/blood
MH  - Leptin/blood
MH  - Prediabetic State/blood/etiology/*physiopathology
MH  - Rats
MH  - Rats, Inbred Dahl
MH  - Telemetry
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Weight Gain
PMC - PMC3247849
EDAT- 2011/11/24 06:00
MHDA- 2012/04/04 06:00
PMCR- 2011/11/22
CRDT- 2011/11/24 06:00
PHST- 2011/09/12 00:00 [received]
PHST- 2011/11/22 00:00 [accepted]
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
PHST- 2011/11/22 00:00 [pmc-release]
AID - 1475-2840-10-104 [pii]
AID - 10.1186/1475-2840-10-104 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2011 Nov 22;10:104. doi: 10.1186/1475-2840-10-104.