PMID- 22108781
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20120703
IS  - 1573-7217 (Electronic)
IS  - 0167-6806 (Linking)
VI  - 133
IP  - 3
DP  - 2012 Jun
TI  - Investigation of human JC and BK polyomaviruses in breast carcinomas.
PG  - 969-77
LID - 10.1007/s10549-011-1876-5 [doi]
AB  - We have previously showed the presence of the simian virus 40 (SV40) and the 
      mouse mammary tumor virus (MMTV)-like in a significant proportions of Tunisian 
      breast carcinomas. However, to date there are no published studies concerning 
      evaluation of the possible implication of the human polyomaviruses JC (JCV) and 
      BK (BKV) in breast carcinomas. The presence of JCV and BKV DNA was investigated 
      by PCR in a 123 primary breast carcinomas and matched adjacent non-tumor breast 
      tissues. The results were correlated to clinicopathological and virological 
      parameters. JCV T-antigen DNA was detected in 23% of breast carcinoma cases; 
      however, all cases were negative for BKV. JCV T antigen PCR products were further 
      confirmed as authentic JCV genome by direct sequencing. JCV was found in invasive 
      ductal carcinomas (28/112 cases) but not in invasive lobular carcinomas (0/5) or 
      medullary carcinomas (0/6). JCV DNA presence correlates inversely with the 
      expression of estrogen (P = 0.022) and progesterone (P = 0.008) receptors. JCV 
      DNA presence correlates also with "triple negative" phenotype (P = 0.021). With 
      regard to virological data, a trend toward an inverse correlation was noted 
      between the presence of JCV and SV40 (P = 0.06). Moreover, significant 
      correlation was found between multiple viral infection (JCV, and/or SV40, and/or 
      MMTV-like in the same tumor) and "triple negative" phenotype (P = 0.001) and also 
      with p53 accumulation (P = 0.028). To the best of our knowledge, this is the 
      first study demonstrating the presence of JCV in a subset of breast carcinomas. 
      Also our results suggest that "triple negative" breast carcinomas are 
      viral-related tumors.
FAU - Hachana, Mohamed
AU  - Hachana M
AD  - Department of Pathology, Farhat Hached Hospital, 4000 Sousse, Tunisia.
FAU - Amara, Khaled
AU  - Amara K
FAU - Ziadi, Sonia
AU  - Ziadi S
FAU - Gacem, Riadh Ben
AU  - Gacem RB
FAU - Korbi, Sadok
AU  - Korbi S
FAU - Trimeche, Mounir
AU  - Trimeche M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111123
PL  - Netherlands
TA  - Breast Cancer Res Treat
JT  - Breast cancer research and treatment
JID - 8111104
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Aged
MH  - BK Virus/*genetics/metabolism
MH  - Base Sequence
MH  - Breast Neoplasms/diagnosis/mortality/*virology
MH  - Carcinoma/diagnosis/mortality/*virology
MH  - Cell Transformation, Viral/genetics
MH  - DNA, Viral
MH  - Female
MH  - Humans
MH  - JC Virus/*genetics/metabolism
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Neoplasm Staging
MH  - Sequence Alignment
MH  - Tunisia
MH  - Young Adult
EDAT- 2011/11/24 06:00
MHDA- 2012/11/07 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/02/16 00:00 [received]
PHST- 2011/11/04 00:00 [accepted]
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
AID - 10.1007/s10549-011-1876-5 [doi]
PST - ppublish
SO  - Breast Cancer Res Treat. 2012 Jun;133(3):969-77. doi: 10.1007/s10549-011-1876-5. 
      Epub 2011 Nov 23.