PMID- 22108978
OWN - NLM
STAT- MEDLINE
DCOM- 20120409
LR  - 20211021
IS  - 1094-4087 (Electronic)
IS  - 1094-4087 (Linking)
VI  - 19
IP  - 22
DP  - 2011 Oct 24
TI  - Motion correction for phase-resolved dynamic optical coherence tomography imaging 
      of rodent cerebral cortex.
PG  - 21258-70
LID - 10.1364/OE.19.021258 [doi]
AB  - Cardiac and respiratory motions in animals are the primary source of image 
      quality degradation in dynamic imaging studies, especially when using 
      phase-resolved imaging modalities such as spectral-domain optical coherence 
      tomography (SD-OCT), whose phase signal is very sensitive to movements of the 
      sample. This study demonstrates a method with which to compensate for motion 
      artifacts in dynamic SD-OCT imaging of the rodent cerebral cortex. We observed 
      that respiratory and cardiac motions mainly caused, respectively, bulk image 
      shifts (BISs) and global phase fluctuations (GPFs). A cross-correlation 
      maximization-based shift correction algorithm was effective in suppressing BISs, 
      while GPFs were significantly reduced by removing axial and lateral global phase 
      variations. In addition, a non-origin-centered GPF correction algorithm was 
      examined. Several combinations of these algorithms were tested to find an 
      optimized approach that improved image stability from 0.5 to 0.8 in terms of the 
      cross-correlation over 4 s of dynamic imaging, and reduced phase noise by two 
      orders of magnitude in ~8% voxels.
CI  - (c) 2011 Optical Society of America
FAU - Lee, Jonghwan
AU  - Lee J
AD  - Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard 
      Medical School, 149 Thirteenth Street, Charlestown, MA 02129, USA. 
      jonghwan@nmr.mgh.harvard.edu
FAU - Srinivasan, Vivek
AU  - Srinivasan V
FAU - Radhakrishnan, Harsha
AU  - Radhakrishnan H
FAU - Boas, David A
AU  - Boas DA
LA  - eng
GR  - K99 NS067050/NS/NINDS NIH HHS/United States
GR  - R01EB000790/EB/NIBIB NIH HHS/United States
GR  - R01 EB001954/EB/NIBIB NIH HHS/United States
GR  - R01 EB001954-09/EB/NIBIB NIH HHS/United States
GR  - R01-EB001954/EB/NIBIB NIH HHS/United States
GR  - R01NS057476/NS/NINDS NIH HHS/United States
GR  - P01 NS055104/NS/NINDS NIH HHS/United States
GR  - P41 EB015896/EB/NIBIB NIH HHS/United States
GR  - P01NS055104/NS/NINDS NIH HHS/United States
GR  - R01 NS057476/NS/NINDS NIH HHS/United States
GR  - K99NS067050/NS/NINDS NIH HHS/United States
GR  - R01 EB000790/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Opt Express
JT  - Optics express
JID - 101137103
SB  - IM
MH  - Algorithms
MH  - Animals
MH  - *Artifacts
MH  - Cerebral Cortex/*anatomy & histology/*physiology
MH  - Movement/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tomography, Optical Coherence/*methods
PMC - PMC3386793
MID - NIHMS379691
EDAT- 2011/11/24 06:00
MHDA- 2012/04/10 06:00
PMCR- 2012/10/12
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2012/04/10 06:00 [medline]
PHST- 2012/10/12 00:00 [pmc-release]
AID - 223184 [pii]
AID - 145206 [pii]
AID - 10.1364/OE.19.021258 [doi]
PST - ppublish
SO  - Opt Express. 2011 Oct 24;19(22):21258-70. doi: 10.1364/OE.19.021258.