PMID- 22110476
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20220410
IS  - 1687-5303 (Electronic)
IS  - 1687-5214 (Print)
IS  - 1687-5214 (Linking)
VI  - 2012
DP  - 2012
TI  - Diagnosis and evaluation of nonalcoholic fatty liver disease.
PG  - 145754
LID - 10.1155/2012/145754 [doi]
LID - 145754
AB  - Nonalcoholic fatty liver disease (NAFLD) is the most common cause of elevated 
      liver function tests results, after the commonly investigated causes have been 
      excluded, and frequently coexists with type 2 diabetes mellitus (T2DM) because 
      the conditions have common risk factors. As both T2DM and NAFLD are related to 
      adverse outcomes of the other, diagnosis and valuation of fatty liver is an 
      important part of the management of diabetes. Although noninvasive methods, such 
      as biomarkers, panel markers, and imaging, may support a diagnostic evaluation of 
      NAFLD patients, accurate histopathological findings cannot be achieved without a 
      liver biopsy. As it is important to know whether steatohepatitis and liver 
      fibrosis are present for the management of NAFLD, liver biopsy remains the gold 
      standard for NAFLD diagnosis and evaluation. Therefore, new investigations of the 
      pathogenesis of NAFLD are necessary to develop useful biomarkers that could 
      provide a reliable noninvasive alternative to liver biopsy.
FAU - Obika, Mikako
AU  - Obika M
AD  - Department of General Internal Medicine, Okayama University Hospital, 2-5-1 
      Shikata-cho, Okayama 700-8558, Japan. obika-m@cc.okayama-u.ac.jp
FAU - Noguchi, Hirofumi
AU  - Noguchi H
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111027
PL  - United States
TA  - Exp Diabetes Res
JT  - Experimental diabetes research
JID - 101274844
RN  - 0 (Biomarkers)
SB  - IM
MH  - Apoptosis
MH  - Biomarkers/analysis
MH  - Biopsy
MH  - Diabetes Mellitus, Type 2/complications
MH  - Fatty Liver/complications/*diagnosis/pathology
MH  - Hepatocytes/pathology
MH  - Humans
MH  - Inflammation
MH  - Liver Cirrhosis/diagnosis
MH  - Magnetic Resonance Imaging
MH  - Non-alcoholic Fatty Liver Disease
MH  - Oxidative Stress
MH  - Tomography, X-Ray Computed
MH  - Ultrasonography
PMC - PMC3205741
EDAT- 2011/11/24 06:00
MHDA- 2012/03/27 06:00
PMCR- 2011/10/27
CRDT- 2011/11/24 06:00
PHST- 2011/06/22 00:00 [received]
PHST- 2011/08/31 00:00 [accepted]
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
PHST- 2011/10/27 00:00 [pmc-release]
AID - 10.1155/2012/145754 [doi]
PST - ppublish
SO  - Exp Diabetes Res. 2012;2012:145754. doi: 10.1155/2012/145754. Epub 2011 Oct 27.