PMID- 22111466
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20111124
IS  - 0004-4849 (Print)
IS  - 0004-4849 (Linking)
VI  - 103
IP  - 2
DP  - 2011 Apr-Jun
TI  - Testing 300 patients for alpha-1 antitrypsin deficiency in Caguas, Puerto Rico.
PG  - 23-4
AB  - Alpha-1 Antitrypsin Deficiency (AATD) is an inherited disorder that can cause 
      lung and liver disease in adults and children. Homozygosity for the Z phenotype 
      is the principal cause of AATD. There are about 100,000 people with AATD in the 
      United States (not including the Island of Puerto Rico), and about the same 
      number in Europe. Despite being one of the most common potentially lethal genetic 
      diseases among Caucasian adults, AATD often remains unidentified, in part because 
      related pulmonary symptoms often do not manifest until midlife when significant 
      pulmonary functional degradation has already occurred. Our study aims to 
      determine what is the prevalence of AATD in a specific population in Puerto Rico.
FAU - Correa, Ramonita
AU  - Correa R
AD  - Department of Anatomy, San Juan Bautista School of Medicine, Caguas, Puerto Rico. 
      rcorrea@sanjuanbautista.edu
FAU - Perez, Jorge
AU  - Perez J
FAU - Brugal, Yocasta
AU  - Brugal Y
FAU - Terrasa, Jose
AU  - Terrasa J
FAU - Perez Guma, Jose
AU  - Perez Guma J
FAU - Santana, Arnulfo
AU  - Santana A
FAU - Colon, Edwin
AU  - Colon E
FAU - Puig, Gisela
AU  - Puig G
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Puerto Rico
TA  - Bol Asoc Med P R
JT  - Boletin de la Asociacion Medica de Puerto Rico
JID - 7505267
RN  - 0 (Reagent Kits, Diagnostic)
RN  - 0 (alpha 1-Antitrypsin)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Prevalence
MH  - Puerto Rico/epidemiology
MH  - Reagent Kits, Diagnostic
MH  - Urban Population
MH  - alpha 1-Antitrypsin/*blood/genetics
MH  - alpha 1-Antitrypsin Deficiency/*epidemiology
EDAT- 2011/11/25 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/11/25 06:00
PHST- 2011/11/25 06:00 [entrez]
PHST- 2011/11/25 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
PST - ppublish
SO  - Bol Asoc Med P R. 2011 Apr-Jun;103(2):23-4.