PMID- 22112111
OWN - NLM
STAT- MEDLINE
DCOM- 20120404
LR  - 20211021
IS  - 1560-2281 (Electronic)
IS  - 1083-3668 (Print)
IS  - 1083-3668 (Linking)
VI  - 16
IP  - 11
DP  - 2011 Nov
TI  - High-resolution imaging diagnosis of human fetal membrane by three-dimensional 
      optical coherence tomography.
PG  - 116006
LID - 10.1117/1.3646530 [doi]
LID - 116006
AB  - Microscopic chorionic pseudocyst (MCP) arising in the chorion leave of the human 
      fetal membrane (FM) is a clinical precursor for preeclampsia which may progress 
      to fatal medical conditions (e.g., abortion) if left untreated. To examine the 
      utility of three-dimensional (3D) optical coherence tomography (OCT) for 
      noninvasive delineation of the morphology of human fetal membranes and early 
      clinical detection of MCP, 60 human FM specimens were acquired from 10 different 
      subjects undergoing term cesarean delivery for an ex vivo feasibility study. Our 
      results showed that OCT was able to identify the four-layer architectures of 
      human FMs consisting of high-scattering decidua vera (DV, average thickness d(DV) 
       approximately  92+/-38 mum), low-scattering chorion and trophoblast (CT, d(CT)  approximately  150+/-67 mum), 
      high-scattering subepithelial amnion (A, d(A)  approximately  95+/-36 mum), and low-scattering 
      epithelium (E, d(E)  approximately  29+/-8 mum). Importantly, 3D OCT was able to instantaneously 
      detect MCPs (low scattering due to edema, fluid buildup, vasodilatation) and 
      track (staging) their thicknesses d(MCP) ranging from 24 to 615 mum. It was also 
      shown that high-frequency ultrasound was able to compliment OCT for detecting 
      more advanced thicker MCPs (e.g., d(MCP)>615 mum) because of its increased imaging 
      depth.
FAU - Ren, Hugang
AU  - Ren H
AD  - Stony Brook University, Department of Biomedical Engineering, Stony Brook, New 
      York 11794-5281, USA.
FAU - Avila, Cecilia
AU  - Avila C
FAU - Kaplan, Cynthia
AU  - Kaplan C
FAU - Pan, Yingtian
AU  - Pan Y
LA  - eng
GR  - 2R01-DK059265/DK/NIDDK NIH HHS/United States
GR  - RC1 DA028534/DA/NIDA NIH HHS/United States
GR  - 1R21-DA032228/DA/NIDA NIH HHS/United States
GR  - R21 DA032228/DA/NIDA NIH HHS/United States
GR  - R01 DK059265/DK/NIDDK NIH HHS/United States
GR  - 1RC-1DA028534/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Opt
JT  - Journal of biomedical optics
JID - 9605853
SB  - IM
MH  - Cysts/chemistry/diagnosis/pathology
MH  - Extraembryonic Membranes/*anatomy & histology/chemistry/diagnostic 
      imaging/*pathology
MH  - Female
MH  - Fetal Diseases/*diagnosis/diagnostic imaging/pathology
MH  - Histocytochemistry
MH  - Humans
MH  - Imaging, Three-Dimensional/*methods
MH  - Pre-Eclampsia/diagnostic imaging/*pathology
MH  - Pregnancy
MH  - Tomography, Optical Coherence/*methods
MH  - Trophoblasts/chemistry
MH  - Ultrasonography
PMC - PMC3221713
EDAT- 2011/11/25 06:00
MHDA- 2012/04/05 06:00
PMCR- 2012/10/26
CRDT- 2011/11/25 06:00
PHST- 2011/11/25 06:00 [entrez]
PHST- 2011/11/25 06:00 [pubmed]
PHST- 2012/04/05 06:00 [medline]
PHST- 2012/10/26 00:00 [pmc-release]
AID - 012111JBO [pii]
AID - 10.1117/1.3646530 [doi]
PST - ppublish
SO  - J Biomed Opt. 2011 Nov;16(11):116006. doi: 10.1117/1.3646530.