PMID- 22113751
OWN - NLM
STAT- MEDLINE
DCOM- 20120427
LR  - 20191112
IS  - 1898-018X (Electronic)
IS  - 1898-018X (Linking)
VI  - 18
IP  - 6
DP  - 2011
TI  - Baseline aortic pre-ejection interval predicts reverse remodeling and clinical 
      improvement after cardiac resynchronization therapy.
PG  - 639-47
AB  - BACKGROUND: Cardiac resynchronization therapy (CRT) has been shown to reduce 
      heart failure-related morbidity and mortality. However, approximately one in 
      three patients do not respond to CRT. The aim of the current study was to 
      determine the parameter(s) which predict reverse remodeling and clinical 
      improvement after CRT. METHODS: A total of 54 patients (43 male, 11 female; mean 
      age 61.9 +/- 10.5 years) with heart failure and New York Heart Association (NYHA) 
      class III-IV symptoms and in whom left ventricular ejection fraction (LVEF) was  pound 
      35% and QRS duration was >/= 120 ms, despite optimal medical therapy, were 
      enrolled. An echocardiographic examination was performed before, and six months 
      after, CRT. An echocardiographic response was defined as a reduction of 
      end-systolic volume >/= 10% after six months, and a clinical response was defined 
      as a reduction >/= 1 in the NYHA functional class score. RESULTS: An 
      echocardiographic response was observed in 38 (70.4%) of the patients and a 
      clinical response occurred in 41 (75.9%) of the patients. Of the dyssynchrony 
      parameters, only the aortic pre-ejection interval (APEI) was observed to 
      significantly predict the clinical response (p = 0.048) and echocardiographic 
      response (p = 0.037). A 180.5 ms cut-off value for the APEI predicted the 
      clinical response with a sensitivity of 92.3% and a specificity of 39%, and the 
      echocardiographic response with a sensitivity of 93.0% and a specificity of 42%. 
      CONCLUSIONS: APEI derived from pulsed-wave Doppler, which is available in every 
      echocardiography machine, is a simple and practical method that could be used to 
      select patients for CRT.
FAU - Aksoy, Hakan
AU  - Aksoy H
AD  - Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, 
      Turkey.
FAU - Okutucu, Sercan
AU  - Okutucu S
FAU - Aytemir, Kudret
AU  - Aytemir K
FAU - Kaya, Ergun Baris
AU  - Kaya EB
FAU - Evranos, Banu
AU  - Evranos B
FAU - Kabakci, Giray
AU  - Kabakci G
FAU - Tokgozoglu, Lale
AU  - Tokgozoglu L
FAU - Ozkutlu, Hilmi
AU  - Ozkutlu H
FAU - Oto, Ali
AU  - Oto A
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Cardiol J
JT  - Cardiology journal
JID - 101392712
SB  - IM
MH  - Aged
MH  - Aortic Valve/diagnostic imaging/*physiopathology
MH  - *Cardiac Resynchronization Therapy
MH  - Chi-Square Distribution
MH  - Echocardiography, Doppler, Color
MH  - Echocardiography, Doppler, Pulsed
MH  - Female
MH  - Heart Failure/diagnostic imaging/physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Patient Selection
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Stroke Volume
MH  - Time Factors
MH  - Treatment Outcome
MH  - Turkey
MH  - Ventricular Dysfunction, Left/diagnostic imaging/physiopathology/*therapy
MH  - *Ventricular Function, Left
MH  - *Ventricular Remodeling
EDAT- 2011/11/25 06:00
MHDA- 2012/04/28 06:00
CRDT- 2011/11/25 06:00
PHST- 2011/11/25 06:00 [entrez]
PHST- 2011/11/25 06:00 [pubmed]
PHST- 2012/04/28 06:00 [medline]
AID - 10.5603/cj.2011.0027 [doi]
PST - ppublish
SO  - Cardiol J. 2011;18(6):639-47. doi: 10.5603/cj.2011.0027.