PMID- 22114149
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20211021
IS  - 1522-1504 (Electronic)
IS  - 1040-0605 (Print)
IS  - 1040-0605 (Linking)
VI  - 302
IP  - 3
DP  - 2012 Feb 1
TI  - Alcohol reduces airway hyperresponsiveness (AHR) and allergic airway inflammation 
      in mice.
PG  - L308-15
LID - 10.1152/ajplung.00077.2011 [doi]
AB  - There is very limited knowledge about the effects of alcohol on airway 
      hyperresponsiveness and inflammation in asthma. Historical accounts of alcohol 
      administration to patients with breathing problems suggest that alcohol may have 
      bronchodilating properties. We hypothesized that alcohol exposure will alter 
      airway hyperresponsiveness (AHR) and pulmonary inflammation in a mouse model of 
      allergic asthma. To test this hypothesis, BALB/c mice were fed either 18% alcohol 
      or water and then sensitized and challenged with ovalbumin (OVA). AHR was 
      assessed by means of ventilation or barometric plethysmography and reported as 
      either total lung resistance or enhanced pause, respectively. Airway inflammation 
      was assessed by total and differential cell counts in bronchoalveolar lavage 
      fluid (BALF), cytokine levels in BALF, lung histology, and serum immunoglobulin E 
      (IgE) levels. Alcohol feeding significantly blocked methacholine-induced 
      increases in AHR compared with water-fed controls. Alcohol feeding significantly 
      reduced total cell numbers (64%) as well as the number of eosinophils (84%) 
      recruited to the lungs of these mice. Modest changes in lung pathology were also 
      observed. Alcohol exposure led to a reduction of IgE in the serum of the EtOH OVA 
      mice. These data demonstrate that alcohol exposure blunts AHR and dampens 
      allergic airway inflammation indices in allergic mice and suggest that there may 
      be an important role for alcohol in the modulation of asthma. These data provide 
      an in vivo basis for previous clinical observations in humans substantiating the 
      bronchodilator properties of alcohol and for the first time demonstrates an 
      alcohol-induced reduction of allergic inflammatory cells in a mouse model of 
      allergic asthma.
FAU - Oldenburg, Peter J
AU  - Oldenburg PJ
AD  - Nebraska Medical Center, Univ. of Nebraska Medical Ctr., Omaha, NE 68198-5910, 
      USA.
FAU - Poole, Jill A
AU  - Poole JA
FAU - Sisson, Joseph H
AU  - Sisson JH
LA  - eng
GR  - R01 ES019325/ES/NIEHS NIH HHS/United States
GR  - 5R37AA008769/AA/NIAAA NIH HHS/United States
GR  - 1K99AA019744-01/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111123
PL  - United States
TA  - Am J Physiol Lung Cell Mol Physiol
JT  - American journal of physiology. Lung cellular and molecular physiology
JID - 100901229
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Bronchoconstrictor Agents)
RN  - 0 (Cytokines)
RN  - 0 (PPAR gamma)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3K9958V90M (Ethanol)
RN  - 9006-59-1 (Ovalbumin)
RN  - JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology/therapeutic use
MH  - Asthma/*chemically induced/drug therapy/prevention & control
MH  - Bronchoalveolar Lavage Fluid
MH  - Bronchoconstriction/drug effects
MH  - Bronchoconstrictor Agents/pharmacology
MH  - Calcitonin Gene-Related Peptide/metabolism
MH  - Cell Count
MH  - Cell Line
MH  - Cytokines/metabolism
MH  - Eosinophils/pathology
MH  - Ethanol/*pharmacology/therapeutic use
MH  - Goblet Cells/drug effects/pathology
MH  - Immunoglobulin E/blood
MH  - Inflammation/*chemically induced/drug therapy/prevention & control
MH  - Lung/drug effects/*pathology
MH  - Male
MH  - Metaplasia/prevention & control
MH  - Methacholine Chloride/pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin
MH  - PPAR gamma/metabolism
MH  - Th2 Cells/metabolism
PMC - PMC3289271
EDAT- 2011/11/25 06:00
MHDA- 2012/03/23 06:00
PMCR- 2013/02/01
CRDT- 2011/11/25 06:00
PHST- 2011/11/25 06:00 [entrez]
PHST- 2011/11/25 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
PHST- 2013/02/01 00:00 [pmc-release]
AID - ajplung.00077.2011 [pii]
AID - L-00077-2011 [pii]
AID - 10.1152/ajplung.00077.2011 [doi]
PST - ppublish
SO  - Am J Physiol Lung Cell Mol Physiol. 2012 Feb 1;302(3):L308-15. doi: 
      10.1152/ajplung.00077.2011. Epub 2011 Nov 23.