PMID- 22115828
OWN - NLM
STAT- MEDLINE
DCOM- 20120522
LR  - 20131121
IS  - 1873-3344 (Electronic)
IS  - 0162-0134 (Linking)
VI  - 106
IP  - 1
DP  - 2012 Jan
TI  - Synthesis and cellular impact of diene-ruthenium(II) complexes: a new class of 
      organoruthenium anticancer agents.
PG  - 126-33
LID - 10.1016/j.jinorgbio.2011.08.027 [doi]
AB  - The cytostatic properties and cellular effects of novel diene-ruthenium(II) 
      complexes of the types OC-6-13-[RuCl(2)(pp)(cod)] 1-5 (pp=2,2'-bipyridyl (bpy), 
      phen=1,10-phenanthroline (phen), 5,6-dimethylphenanthroline (5,6-Me2phen), 
      dipyrido[3,2-d:2',3'-f]quinoxaline (dpq), ethylenediamine (en)) and 
      OC-6-24-[RuCl(Me(2)N)(2)CS(pp)(cod)](CF(3)SO(3)) 6-8 (pp=phen, 5,6-Me(2)phen, 
      dpq) have been studied for the human cancer cell lines MCF-7 and HT-29 and for 
      Jurkat leukemia cells. CD spectra indicate that 7 causes a massive distortion of 
      the CT DNA B double helix toward the A form. Whereas the neutral complexes 1, 2 
      and 5 exhibit only modest antiproliferative activity toward MCF-7 and HT-29 
      cells, the monocationic complexes are significantly more active, in particular 
      the DNA-distorting complex 7 with its IC(50) values of 0.73 and 0.42 muM, 
      respectively. As established by online monitoring with a cell-based sensor chip, 
      this potent 5,6-Me(2)phen complex invokes dose-dependent decreases in MCF-7 
      cellular respiration and extracellular acidification rates and causes a 
      time-delayed decrease in the impedance of the cell layers, that can be ascribed 
      to cell death. Treatment of Jurkat cells with 7 leads to high concentrations of 
      reactive oxygen species and the induction of apoptosis. The pronounced 
      dose-dependent inhibition of oxygen consumption by isolated mice mitochondria 
      indicates the involvement of an intrinsic mitochondrial pathway in the programmed 
      cell death process.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Kasper, Christine
AU  - Kasper C
AD  - Fakultat fur Chemie und Biochemie, Ruhr-Universitat Bochum, Bochum, Germany.
FAU - Alborzinia, Hamed
AU  - Alborzinia H
FAU - Can, Suzan
AU  - Can S
FAU - Kitanovic, Igor
AU  - Kitanovic I
FAU - Meyer, Andreas
AU  - Meyer A
FAU - Geldmacher, Yvonne
AU  - Geldmacher Y
FAU - Oleszak, Melanie
AU  - Oleszak M
FAU - Ott, Ingo
AU  - Ott I
FAU - Wolfl, Stefan
AU  - Wolfl S
FAU - Sheldrick, William S
AU  - Sheldrick WS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110914
PL  - United States
TA  - J Inorg Biochem
JT  - Journal of inorganic biochemistry
JID - 7905788
RN  - 0 (Antineoplastic Agents)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Hydrocarbons)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Reactive Oxygen Species)
RN  - 7UI0TKC3U5 (Ruthenium)
SB  - IM
MH  - Antineoplastic Agents/chemical synthesis/*chemistry/pharmacology
MH  - Apoptosis/drug effects
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Cell Respiration/drug effects
MH  - DNA, Neoplasm/chemistry/genetics
MH  - Dose-Response Relationship, Drug
MH  - Extracellular Space/chemistry/drug effects
MH  - HT29 Cells
MH  - Humans
MH  - Hydrocarbons/*chemistry
MH  - Hydrogen-Ion Concentration/drug effects
MH  - Intracellular Space/drug effects/metabolism
MH  - Jurkat Cells
MH  - Nucleic Acid Conformation/drug effects
MH  - Organometallic Compounds/chemical synthesis/*chemistry/pharmacology
MH  - Oxygen Consumption/drug effects
MH  - Reactive Oxygen Species/metabolism
MH  - Ruthenium/*chemistry
EDAT- 2011/11/26 06:00
MHDA- 2012/05/23 06:00
CRDT- 2011/11/26 06:00
PHST- 2011/06/09 00:00 [received]
PHST- 2011/07/30 00:00 [revised]
PHST- 2011/08/19 00:00 [accepted]
PHST- 2011/11/26 06:00 [entrez]
PHST- 2011/11/26 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - S0162-0134(11)00260-1 [pii]
AID - 10.1016/j.jinorgbio.2011.08.027 [doi]
PST - ppublish
SO  - J Inorg Biochem. 2012 Jan;106(1):126-33. doi: 10.1016/j.jinorgbio.2011.08.027. 
      Epub 2011 Sep 14.