PMID- 22115920
OWN - NLM
STAT- MEDLINE
DCOM- 20120711
LR  - 20181201
IS  - 1879-0291 (Electronic)
IS  - 0141-1136 (Linking)
VI  - 76
DP  - 2012 May
TI  - Lindane toxicity: histopathological, behavioural and biochemical changes in 
      Etroplus maculatus (Bloch, 1795).
PG  - 63-70
LID - 10.1016/j.marenvres.2011.10.011 [doi]
AB  - The effects of sub-lethal concentrations of lindane on behavioral, hematological 
      and histological parameters in Etroplus maculatus were investigated. The LC(5)(0) 
      value of lindane for E. maculatus was estimated using the Probit method and was 
      found to be 0.028 mg/L. The red blood cell count (RBC) and the hemoglobin (Hb), 
      hematocrit (Ht), mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV) 
      and mean corpuscular hemoglobin concentration (MCHC) were significantly reduced 
      (p > 0.0001) in fish exposed to the toxicant concentrations compared to the 
      control groups. However, the white blood cell count (WBC) was observed to be 
      significantly higher (p < 0.0001). Observations of the tissues showed that 
      lindane had profound destructive effects on the gills, liver and kidney of the 
      fish. The gills showed proliferation of the lamellar epithelium and lamellar 
      fusion, the liver showed necrosis and the kidneys had constriction of the tubular 
      lumen. The frequency of observed behaviors had the same levels of significance 
      throughout the period of study. There was a reduction in the frequency of 
      occurrence between test concentrations, but remained significantly higher than 
      the control. The study shows that lindane is harmful to E. maculatus at 
      sub-lethal concentrations and that the application of this pesticide close to 
      bodies of water is a dangerous threat to aquatic life.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Bijoy Nandan, S
AU  - Bijoy Nandan S
AD  - Department of Marine Biology, Microbiology & Biochemistry, School of Marine 
      Sciences, Cochin University of Science and Technology, Fine Arts Avenue, Cochin 
      682016, Kerala, India. bijoynandan@yahoo.co.in
FAU - Nimila, P J
AU  - Nimila PJ
LA  - eng
PT  - Journal Article
DEP - 20111110
PL  - England
TA  - Mar Environ Res
JT  - Marine environmental research
JID - 9882895
RN  - 0 (Water Pollutants, Chemical)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Blood Cells/drug effects
MH  - Cichlids/*physiology
MH  - Gills/drug effects
MH  - Hexachlorocyclohexane/*toxicity
MH  - Kidney/drug effects
MH  - Lethal Dose 50
MH  - Liver/drug effects
MH  - Water Pollutants, Chemical/*toxicity
EDAT- 2011/11/26 06:00
MHDA- 2012/07/12 06:00
CRDT- 2011/11/26 06:00
PHST- 2011/06/22 00:00 [received]
PHST- 2011/10/28 00:00 [revised]
PHST- 2011/10/31 00:00 [accepted]
PHST- 2011/11/26 06:00 [entrez]
PHST- 2011/11/26 06:00 [pubmed]
PHST- 2012/07/12 06:00 [medline]
AID - S0141-1136(11)00144-9 [pii]
AID - 10.1016/j.marenvres.2011.10.011 [doi]
PST - ppublish
SO  - Mar Environ Res. 2012 May;76:63-70. doi: 10.1016/j.marenvres.2011.10.011. Epub 
      2011 Nov 10.