PMID- 22116023
OWN - NLM
STAT- MEDLINE
DCOM- 20120309
LR  - 20220316
IS  - 1769-6658 (Electronic)
IS  - 1278-3218 (Linking)
VI  - 15
IP  - 8
DP  - 2011 Dec
TI  - [Intensity-modulated radiotherapy and involved-node concept in patients with 
      Hodgkin lymphoma: experience of the Gustave-Roussy Institute].
PG  - 709-15
LID - 10.1016/j.canrad.2011.05.014 [doi]
AB  - PURPOSE: To assess the clinical outcome of the involved-node radiotherapy concept 
      with the use of intensity modulated radiotherapy (IMRT) in patients with 
      localized supradiaphragmatic Hodgkin lymphoma. PATIENTS AND METHODS: Patients 
      with early-stage supradiaphragmatic Hodgkin lymphoma were treated with 
      chemotherapy prior to irradiation. Radiation treatments were delivered using the 
      involved-node radiotherapy (INRT) concept according to the EORTC guidelines. 
      Intensity modulated radiotherapy was performed free-breathing. RESULTS: 
      Forty-seven patients with Hodgkin lymphoma (44 patients with primary Hodgkin 
      lymphoma and three patients with recurrent disease) entered the study from 
      January 2003 to December 2010. The median age was 31 years (range 17 to 62). 
      Thirty patients had stage I-IIA, 14 had stage I-IIB disease and three had 
      relapse. Forty-two patients received three to six cycles of adriamycin, 
      bleomycin, vinblastine and dacarbazine (ABVD). The median radiation dose to 
      patients was 36 Gy (range: 20-40). Protection of various organs at risk was 
      satisfactory. The median follow-up was 57.4 months (range: 5.4-94.3). For 
      patients with primary Hodgkin lymphoma, the 5-year survival and 5-year 
      progression-free survival rates were 96% (95% confidence interval: 80-99) and 92% 
      (95% confidence interval: 78-97), respectively. None of the three patients with 
      recurrent disease has relapsed. Recurrences occurred in three patients: one was 
      in-field relapse and two were visceral recurrences. Grade 3 acute lung toxicity 
      (transient pneumonitis) occurred in one case. CONCLUSION: Our results suggest 
      that patients with localized Hodgkin lymphoma can be safely and efficiently 
      treated using the involved node irradiation concept and intensity modulated 
      irradiation.
CI  - Copyright (c) 2011. Published by Elsevier SAS.
FAU - Paumier, A
AU  - Paumier A
AD  - Departement de Radiotherapie, Institut de Cancerologie Gustave-Roussy, 114, rue 
      Edouard-Vaillant, 94805 Villejuif, France. amaury.paumier@igr.fr
FAU - Khodari, W
AU  - Khodari W
FAU - Beaudre, A
AU  - Beaudre A
FAU - Ghalibafian, M
AU  - Ghalibafian M
FAU - Blanchard, P
AU  - Blanchard P
FAU - Al Hamokles, H
AU  - Al Hamokles H
FAU - Bhari, M
AU  - Bhari M
FAU - Lessard, N
AU  - Lessard N
FAU - Girinsky, T
AU  - Girinsky T
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Optimisation de l'<< involved-node radiotherapy >> par l'utilisation de la 
      modulation d'intensite dans le lymphome hodgkinien localise : experience de 
      l'institut Gustave-Roussy.
DEP - 20111123
PL  - France
TA  - Cancer Radiother
JT  - Cancer radiotherapie : journal de la Societe francaise de radiotherapie 
      oncologique
JID - 9711272
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Health Facilities
MH  - Hodgkin Disease/pathology/*radiotherapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Radiotherapy, Intensity-Modulated
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2011/11/26 06:00
MHDA- 2012/03/10 06:00
CRDT- 2011/11/26 06:00
PHST- 2011/02/12 00:00 [received]
PHST- 2011/04/26 00:00 [revised]
PHST- 2011/05/22 00:00 [accepted]
PHST- 2011/11/26 06:00 [entrez]
PHST- 2011/11/26 06:00 [pubmed]
PHST- 2012/03/10 06:00 [medline]
AID - S1278-3218(11)00426-4 [pii]
AID - 10.1016/j.canrad.2011.05.014 [doi]
PST - ppublish
SO  - Cancer Radiother. 2011 Dec;15(8):709-15. doi: 10.1016/j.canrad.2011.05.014. Epub 
      2011 Nov 23.