PMID- 22116285
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20211021
IS  - 0973-7138 (Electronic)
IS  - 0250-5991 (Linking)
VI  - 36
IP  - 5
DP  - 2011 Dec
TI  - Polyopes affinis alleviates airway inflammation in a murine model of allergic 
      asthma.
PG  - 869-77
AB  - Marine algae have been utilized in food as well as medicine products for a 
      variety of purposes. The purpose of this study was to determine whether an 
      ethanol extract of Polyopes affinis (P.affinis) can inhibit the pathogenesis of T 
      helper 2 (Th2)-mediated allergen-induced airway inflammation in a murine model of 
      asthma. Mice that were sensitized and challenged with ovalbumin (OVA) evidenced 
      typical asthmatic reactions such as the following: an increase in the number of 
      eosinophils in the bronchoalveolar lavage (BAL) fluid; a marked influx of 
      inflammatory cells into the lung around blood vessels and airways as well as the 
      narrowing of the airway luminal; the development of airway hyperresponsiveness 
      (AHR); the presence of pulmonary Th2 cytokines; and the presence of 
      allergenspecific immunoglobulin E (IgE) in the serum. The successive 
      intraperitoneal administration of P. affinis ethanolic extracts before the last 
      airway OVA-challenge resulted in a significant inhibition of all asthmatic 
      reactions. These data suggest that P. affinis ethanolic extracts possess 
      therapeutic potential for the treatment of pulmonary allergic disorders such as 
      allergic asthma.
FAU - Lee, Dae-Sung
AU  - Lee DS
AD  - POSTECH Ocean Science and Technology Institute, Pohang University of Science and 
      Technology (POSTECH), Pohang 790-784, Republic of Korea.
FAU - Park, Won Sun
AU  - Park WS
FAU - Heo, Soo-Jin
AU  - Heo SJ
FAU - Cha, Seon-Heui
AU  - Cha SH
FAU - Kim, Daekyung
AU  - Kim D
FAU - Jeon, You-Jin
AU  - Jeon YJ
FAU - Park, Sae-Gwang
AU  - Park SG
FAU - Seo, Su-Kil
AU  - Seo SK
FAU - Choi, Jung Sik
AU  - Choi JS
FAU - Park, Sung-Jae
AU  - Park SJ
FAU - Shim, Eun Bo
AU  - Shim EB
FAU - Choi, Il-Whan
AU  - Choi IW
FAU - Jung, Won-Kyo
AU  - Jung WK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - J Biosci
JT  - Journal of biosciences
JID - 8100809
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Cytokines)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Plant Extracts)
RN  - 0 (Solvents)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3K9958V90M (Ethanol)
RN  - 9006-59-1 (Ovalbumin)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Animals
MH  - Anti-Asthmatic Agents/isolation & purification/*pharmacology
MH  - Asthma/chemically induced/*drug therapy
MH  - Bronchoalveolar Lavage Fluid
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Eosinophils/enzymology
MH  - Ethanol/chemistry
MH  - Female
MH  - Free Radical Scavengers/isolation & purification/*pharmacology
MH  - Immunoglobulin E/blood
MH  - Lung/drug effects/metabolism/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin
MH  - Peroxidase/metabolism
MH  - Plant Extracts/isolation & purification/*pharmacology
MH  - Rhodophyta/*chemistry
MH  - Solvents/chemistry
EDAT- 2011/11/26 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/11/26 06:00
PHST- 2011/11/26 06:00 [entrez]
PHST- 2011/11/26 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - 10.1007/s12038-011-9152-8 [doi]
PST - ppublish
SO  - J Biosci. 2011 Dec;36(5):869-77. doi: 10.1007/s12038-011-9152-8.