PMID- 22117664
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20111128
IS  - 1878-3570 (Electronic)
IS  - 0002-8223 (Linking)
VI  - 111
IP  - 12
DP  - 2011 Dec
TI  - Adverse food reactions--an emerging issue for adults.
PG  - 1877-91
LID - 10.1016/j.jada.2011.09.001 [doi]
AB  - Adverse reactions to foods are classified according to the presence or absence of 
      involvement of the immune system, which may or may not include the production of 
      immunoglobulin E (IgE) antibodies. This review focuses on the epidemiology, 
      diagnosis, and management of adverse food reactions, primarily in adults, and 
      excluding celiac disease and lactose intolerance. Reported reactions to foods are 
      often believed to be manifestations of a food allergy; however, IgE-mediated food 
      allergy only affects 1% to 4% of adults, with seafood, tree nuts, peanuts, 
      fruits, and vegetables being the most common triggers. Diagnosis is challenging 
      and most commonly achieved through careful evaluation of clinical history 
      followed by elimination and reintroduction or challenge with the suspected 
      offending food. With acute-onset allergic reactions, estimation of food-specific 
      IgE antibodies is frequently used to confirm or refute the diagnosis. Recent 
      developments, such as single allergen assays, enhance the diagnosis of 
      IgE-mediated food allergy, but the gold standard remains oral food challenge. 
      Despite recent advances in the management of food allergy, including the 
      promotion of oral tolerance, the mainstay of management is still the avoidance of 
      food triggers. Dietary management can be compromised by nutritional inadequacy, 
      accidental exposure, food labeling, and quality of life or adherence issues. It 
      is essential that adults with confirmed food allergy receive optimal nutrition 
      and dietetic support to enable them to manage their condition.
CI  - Copyright (c) 2011 American Dietetic Association. Published by Elsevier Inc. All 
      rights reserved.
FAU - Skypala, Isabel
AU  - Skypala I
AD  - Royal Brompton & Harefield NHS Foundation Trust, London, UK. 
      i.skypala@rbht.nhs.uk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Am Diet Assoc
JT  - Journal of the American Dietetic Association
JID - 7503061
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Allergens/*immunology
MH  - Diagnosis, Differential
MH  - *Food Hypersensitivity/diagnosis/epidemiology/immunology/therapy
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Medical History Taking
MH  - *Nutrition Therapy
MH  - Quality of Life
EDAT- 2011/11/29 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/11/29 06:00
PHST- 2010/03/29 00:00 [received]
PHST- 2011/05/20 00:00 [accepted]
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
AID - S0002-8223(11)01543-4 [pii]
AID - 10.1016/j.jada.2011.09.001 [doi]
PST - ppublish
SO  - J Am Diet Assoc. 2011 Dec;111(12):1877-91. doi: 10.1016/j.jada.2011.09.001.