PMID- 22117902
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 79
IP  - 2
DP  - 2012 Feb
TI  - Genetic response to an environmental pathogenic agent: HLA-DQ and onchocerciasis 
      in northwestern Ecuador.
PG  - 123-9
LID - 10.1111/j.1399-0039.2011.01811.x [doi]
AB  - The aim of this study is to explore human leukocyte antigen (HLA)-DQ variability 
      in two populations (Cayapas Amerindians and Afro-Ecuadorians) who live near one 
      another along the Cayapa River and who are exposed to the same environmental 
      stresses, such as infection by Onchocerca volvulus. HLA-DQA1 and HLA-DQB1 of 149 
      unrelated individuals (74 Cayapas and 75 Afro-Ecuadorians) have been analyzed. 
      HLA high-resolution molecular typing was performed by sequence-based typing, 
      sequence-specific oligonucleotides hybridization and sequence-specific primer 
      (SSP) amplification. The comparison between affected (cases) and unaffected 
      people (controls) in both populations shows the key role of several HLA-DQA1 
      alleles in susceptibility and protection against onchocerciasis. In both 
      populations, there is strong evidence related to the protective role of DQA1*0401 
      against onchocerciasis. Alleles HLA-DQA1*0102 and *0103 seem to represent risk 
      factors in Afro-Ecuadorians, while HLA-DQA1*0301 is only a suggestive 
      susceptibility allele in Cayapas. These findings represent new positive/negative 
      associations with onchocerciasis in South America, whereas previous findings 
      pertained only to African populations.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - De Angelis, F
AU  - De Angelis F
AD  - Department of Biology, University of Rome Tor Vergata, Rome, Italy. 
      flavio.de.angelis@uniroma2.it
FAU - Garzoli, A
AU  - Garzoli A
FAU - Battistini, A
AU  - Battistini A
FAU - Iorio, A
AU  - Iorio A
FAU - De Stefano, G F
AU  - De Stefano GF
LA  - eng
PT  - Journal Article
DEP - 20111126
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (DNA Primers)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - American Indian or Alaska Native
MH  - Animals
MH  - Black People
MH  - Case-Control Studies
MH  - Child
MH  - DNA Primers
MH  - Disease Susceptibility
MH  - Ecuador/epidemiology
MH  - Female
MH  - Gene Frequency
MH  - Gene-Environment Interaction
MH  - HLA-DQ alpha-Chains/*genetics/immunology
MH  - HLA-DQ beta-Chains/*genetics/immunology
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nucleic Acid Amplification Techniques
MH  - Onchocerca/*immunology
MH  - Onchocerciasis/ethnology/*genetics/immunology
MH  - Polymorphism, Genetic
EDAT- 2011/11/29 06:00
MHDA- 2012/08/15 06:00
CRDT- 2011/11/29 06:00
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
AID - 10.1111/j.1399-0039.2011.01811.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2012 Feb;79(2):123-9. doi: 10.1111/j.1399-0039.2011.01811.x. 
      Epub 2011 Nov 26.