PMID- 22117988
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20220223
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Linking)
VI  - 39
IP  - 5
DP  - 2011
TI  - The expression and clinical significance of GTP-binding RAS-like 3 (ARHI) and 
      microRNA 221 and 222 in prostate cancer.
PG  - 1870-5
AB  - Globally, prostate cancer is the most common malignancy among men and there is no 
      biomarker for defining tumour invasion and progression. Guanosine-5'-triphosphate 
      (GTP)-binding RAS-like 3 (ARHI) is a tumour suppressor gene that has been found 
      to be downregulated in the prostate cancer cell line PC-3. MicroRNA 221 and 222 
      have been shown to regulate ARHI expression negatively. This study evaluated 
      tissue samples from patients with prostate cancer (n = 35) that were designated 
      as aggressive or non-aggressive according to their Gleason grade. Expression of 
      ARHI and microRNA 221 and 222 was measured by real-time reverse 
      transcription-polymerase chain reaction. The level of ARHI mRNA was significantly 
      lower in aggressive compared with non-aggressive prostate cancer tissue samples. 
      In contrast, microRNA 221 and 222 levels were significantly higher in aggressive 
      compared with non-aggressive prostate cancer tissue samples. Whether ARHI and 
      microRNA 221 and 222 could be considered as biomarkers for disease progression in 
      prostate cancer requires further investigation.
FAU - Lin, D
AU  - Lin D
AD  - Urology Department, The First Affiliated Hospital of Suzhou University, Suzhou, 
      China.
FAU - Cui, F
AU  - Cui F
FAU - Bu, Q
AU  - Bu Q
FAU - Yan, C
AU  - Yan C
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DIRAS3 protein, human)
RN  - 0 (MIRN221 microRNA, human)
RN  - 0 (MIRN222 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - EC 3.6.5.2 (rho GTP-Binding Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/genetics/*metabolism
MH  - *Gene Expression
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Male
MH  - MicroRNAs/genetics/*metabolism
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Prostatic Neoplasms/genetics/*metabolism/pathology
MH  - rho GTP-Binding Proteins/genetics/*metabolism
EDAT- 2011/11/29 06:00
MHDA- 2012/03/31 06:00
CRDT- 2011/11/29 06:00
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
AID - 10.1177/147323001103900530 [doi]
PST - ppublish
SO  - J Int Med Res. 2011;39(5):1870-5. doi: 10.1177/147323001103900530.