PMID- 22118742
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20111128
IS  - 1557-9832 (Electronic)
IS  - 0272-2712 (Linking)
VI  - 31
IP  - 4
DP  - 2011 Dec
TI  - Genetics of chronic lymphocytic leukemia.
PG  - 649-58, ix
LID - 10.1016/j.cll.2011.07.006 [doi]
AB  - Morphology and the immunophenotype of chronic lymphocytic leukemia (CLL) are 
      quite homogenous, but CLL's clinical course is not; some patients are stable for 
      years, others experience rapid progression and poor response to chemotherapy. 
      Fluorescence in situ hybridization (FISH) helped determine why these differences 
      occur. Further progress has been made using comparative genomic hybridization and 
      single nucleotide polymorphism (SNP) array analysis. Now the discovery of further 
      dysregulated cellular pathways and potential new therapeutic targets is possible 
      by genome-wide high-throughput next generation sequencing, which will likely also 
      enter clinical diagnostics.
FAU - Schnaiter, Andrea
AU  - Schnaiter A
AD  - Department of Internal Medicine III, University of Ulm, Albert Einstein Allee 23, 
      89081 Ulm, Germany.
FAU - Mertens, Daniel
AU  - Mertens D
FAU - Stilgenbauer, Stephan
AU  - Stilgenbauer S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111117
PL  - United States
TA  - Clin Lab Med
JT  - Clinics in laboratory medicine
JID - 8100174
RN  - 0 (Immunoglobulin Heavy Chains)
SB  - IM
MH  - Chromosome Aberrations
MH  - Comparative Genomic Hybridization
MH  - Humans
MH  - Immunoglobulin Heavy Chains/genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis/*genetics
MH  - Prognosis
MH  - Survival Analysis
EDAT- 2011/11/29 06:00
MHDA- 2012/06/01 06:00
CRDT- 2011/11/29 06:00
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - S0272-2712(11)00063-1 [pii]
AID - 10.1016/j.cll.2011.07.006 [doi]
PST - ppublish
SO  - Clin Lab Med. 2011 Dec;31(4):649-58, ix. doi: 10.1016/j.cll.2011.07.006. Epub 
      2011 Nov 17.