PMID- 22119438
OWN - NLM
STAT- MEDLINE
DCOM- 20120504
LR  - 20131121
IS  - 1873-426X (Electronic)
IS  - 0008-6215 (Linking)
VI  - 347
IP  - 1
DP  - 2012 Jan 10
TI  - Urinary glycosaminoglycans and glycoproteins in a calcium oxalate crystallization 
      system.
PG  - 64-8
LID - 10.1016/j.carres.2011.09.022 [doi]
AB  - This study measures the effects of total urinary glycosaminoglycans (GAGs), 
      glycoproteins (GPs) and individual GAGs on the nucleation rates (Bo), growth 
      rates (G) and suspension densities (Msmall te, Cyrillic) of calcium oxalate (CaOx) crystallization 
      by the mixed suspension mixed product removal (MSMPR) system. Total urinary GAGs, 
      glycoproteins and individual GAGs including heparan sulfate (HS), chondroitin 
      sulfate (CS) and Hyaluronic acid (HA) were added into the artificial urine (AU) 
      and then introduced into the MSMPR test chamber and the crystal sizes and numbers 
      were analyzed by a particle counter. The effects of added GAGs and GPs on CaOx 
      crystallization were reflected by the changes on the crystallization indexes 
      including the Bo, G and Msmall te, Cyrillic of CaOx that were calculated based on the crystal size 
      and numbers. Total urinary GAGs showed no statistical significance on CaOx 
      crystallization. However, individual GAGs such as HA, CS and HS enhanced Bo and 
      suppressed the G when measured individually. CS and HS enhanced the Msmall te, Cyrillic while HA 
      shown no significant change in the Msmall te, Cyrillic of CaOx. Total urinary GPs showed an 
      increase in the G and Msmall te, Cyrillic of crystals. Although total urinary GAGs showed no 
      statistically significant effect on CaOx crystallization, individual GAGs (CS, 
      HS) promoted the CaOx crystallization by increasing the suspension density of 
      smaller crystals, indicative of reduced risk of stones while HA showed no 
      significance in the M(T) of CaOx formed. Urinary GPs indicated increased sizes 
      and M(T) suggesting larger crystals and/or aggregates.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Poon, Ngork Wah
AU  - Poon NW
AD  - Dept. of Health Technology and Informatics, The Hong Kong Polytechnic University, 
      Hung Hom, Kowloon, Hong Kong.
FAU - Gohel, Mayur Danny I
AU  - Gohel MD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110929
PL  - Netherlands
TA  - Carbohydr Res
JT  - Carbohydrate research
JID - 0043535
RN  - 0 (Glycoproteins)
RN  - 0 (Glycosaminoglycans)
RN  - 2612HC57YE (Calcium Oxalate)
SB  - IM
MH  - Calcium Oxalate/*chemistry
MH  - Crystallization
MH  - Glycoproteins/*pharmacology/*urine
MH  - Glycosaminoglycans/*pharmacology/*urine
MH  - Humans
MH  - Kidney Calculi/metabolism/urine
EDAT- 2011/11/29 06:00
MHDA- 2012/05/05 06:00
CRDT- 2011/11/29 06:00
PHST- 2011/07/15 00:00 [received]
PHST- 2011/09/20 00:00 [revised]
PHST- 2011/09/21 00:00 [accepted]
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2012/05/05 06:00 [medline]
AID - S0008-6215(11)00459-9 [pii]
AID - 10.1016/j.carres.2011.09.022 [doi]
PST - ppublish
SO  - Carbohydr Res. 2012 Jan 10;347(1):64-8. doi: 10.1016/j.carres.2011.09.022. Epub 
      2011 Sep 29.