PMID- 22119485
OWN - NLM
STAT- MEDLINE
DCOM- 20120521
LR  - 20151119
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 28
IP  - 3
DP  - 2012 Mar
TI  - Skim milk powder enhances trabecular bone architecture compared with casein or 
      whey in diet-induced obese rats.
PG  - 331-5
LID - 10.1016/j.nut.2011.07.022 [doi]
AB  - OBJECTIVE: We previously showed that skim milk powder (SMP) prevents weight gain 
      more so than casein or whey alone. Dairy foods and changes in body mass can 
      affect bone architecture; therefore, our objective was to examine the effect of 
      dairy proteins on bone structure in the tibia of dietary-induced obese rats. 
      METHODS: Twelve-week-old diet-induced obese Sprague-Dawley rats were randomized 
      to one of six diets that varied in protein source (casein, whey, or SMP), Ca 
      level (0.67% or 2.4%), and energy density (high-fat/high-sucrose [HFHS], or 
      normal energy density [NE]). After 8 wk, body composition was assessed via dual 
      energy x-ray absorptiometry and trabecular and cortical bone parameters of the 
      tibia were assessed using micro-computed tomography and mixed model analysis. 
      RESULTS: Rats fed SMP with 2.4% calcium had significantly lower body mass and fat 
      mass than all other groups. The ratio of bone volume to total volume (BV/TV) was 
      significantly higher when the HFHS diet was supplemented with SMP and 2.4% 
      calcium compared with whey (+66.7%) or casein (+32.6%). The HFHS diet group had 
      49.3% greater BV/TV compared with the NE groups. Increasing the amount of calcium 
      resulted in a significant increase in BV/TV (188.9%) in the HFHS diet groups but 
      not in the NE groups. CONCLUSION: The intake of skim milk powder supplemented 
      with calcium enhances trabecular bone architecture in obese rats consuming HFHS 
      diet to a greater extent than with either casein or whey protein alone. Bioactive 
      ingredients in complete dairy may contribute to these effects.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Fried, Aviv
AU  - Fried A
AD  - Department of Mechanical and Manufacturing Engineering, University of Calgary, 
      Alberta, Canada.
FAU - Manske, Sarah L
AU  - Manske SL
FAU - Eller, Lindsay K
AU  - Eller LK
FAU - Lorincz, Caeley
AU  - Lorincz C
FAU - Reimer, Raylene A
AU  - Reimer RA
FAU - Zernicke, Ronald F
AU  - Zernicke RF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111125
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - 0 (Calcium, Dietary)
RN  - 0 (Caseins)
RN  - 0 (Milk Proteins)
RN  - 0 (Whey Proteins)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Animals
MH  - Body Composition/drug effects
MH  - Bone Density/drug effects
MH  - Bone and Bones/*drug effects/metabolism
MH  - Calcium, Dietary/administration & dosage
MH  - Caseins/*administration & dosage
MH  - *Diet
MH  - Male
MH  - Milk/*chemistry/metabolism
MH  - Milk Proteins/*administration & dosage
MH  - Obesity/chemically induced/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tomography, X-Ray Computed
MH  - Weight Gain/drug effects
MH  - Whey Proteins
EDAT- 2011/11/29 06:00
MHDA- 2012/05/23 06:00
CRDT- 2011/11/29 06:00
PHST- 2010/12/15 00:00 [received]
PHST- 2011/05/02 00:00 [revised]
PHST- 2011/07/29 00:00 [accepted]
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - S0899-9007(11)00255-3 [pii]
AID - 10.1016/j.nut.2011.07.022 [doi]
PST - ppublish
SO  - Nutrition. 2012 Mar;28(3):331-5. doi: 10.1016/j.nut.2011.07.022. Epub 2011 Nov 
      25.